MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to
regulate gene expression by translational repression 1 . Several miRNAs in animals exhibit …

Infection-related diabetes can arise as a result of virus-associated β-cell destruction.
Clinical data suggest that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), …

The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense interest because
of the potential clinical relevance of this peptide. Produced in intestinal L-cells through …

Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the body.
Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

The appropriate secretion of insulin from pancreatic β-cells is critically important to the
maintenance of energy homeostasis. The β-cells must sense and respond suitably to postprandial …

Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver
glycogen breakdown. The mechanism regulating glucagon release is debated, and variously …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Uncoupling protein 2 (UCP-2) mRNA expression has been shown to be altered by metabolic
conditions such as obesity in humans, but its functional significance is unknown. The …

Paracrine interactions between pancreatic islet cells have been proposed as a mechanism
to regulate hormone secretion and glucose homeostasis. Here, we demonstrate the …

In pancreatic β-cells, voltage-dependent K + (Kv) channels are potential mediators of
repolarization, closure of Ca 2+ channels, and limitation of insulin secretion. The specific Kv …