Background More than 30 percent of patients with epilepsy have inadequate control of seizures
with drug therapy, but why this happens and whether it can be predicted are unknown. …

Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines
how this diagnosis should be established and how to recognize pseudoresistance. It …

Importance A study published in 2000 showed that more than one-third of adults with epilepsy
have inadequate control of seizures with antiepileptic drugs (AEDs). This study evaluates …

A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele
and carbamazepine‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese subjects…

Purpose: To investigate the interaction among efficacy, tolerability, and overall effectiveness
of the first antiepileptic drug (AED) in patients with newly diagnosed epilepsy. Methods: The …

To improve patient care and facilitate clinical research, the International League Against
Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant …

Epilepsy and its treatment can have deleterious cognitive and behavioural consequences.
Affected individuals have a higher prevalence of neuropsychological dysfunction than the …

Objective: To evaluate the efficacy and safety of perampanel 2, 4, and 8 mg/day added to 1–3
concomitant antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures. …

When and how a combination of antiepileptic drugs (AEDs) should be used in patients
unresponsive to monotherapy is not known. We followed up prospectively 248 patients in whom …

In the past decade, nine new drugs have been licensed for the treatment of epilepsy. With
limited clinical experience of these agents, the mechanisms of action of antiepileptic drugs …