Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide
deaths, respectively, due largely to broad increased risk for disease and injury 1 , 2 , 3 – …

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory
arthritis. By combining data from >140,000 individuals of European ancestry within the Global …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …

We conducted a meta-analysis of genome-wide association data to detect genes influencing
age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10 −9 ), …

Hypertension places a major burden on individual and public health, but the genetic basis
of this complex disorder is poorly understood. We conducted a genome-wide association …

The genetic architecture of human reproductive behavior—age at first birth (AFB) and number
of children ever born (NEB)—has a strong relationship with fitness, human development, …