E2F is a family of transcription factors that regulate both cellular proliferation and differentiation.
To establish the role of E2F3 in vivo, we generated an E2f3 mutant mouse strain. E2F3-…

T cell shape is dictated by the selective recruitment of molecules to different regions of the
cell (polarity) and is integral to every aspect of T cell function, from migration to cytotoxicity. …

The mammalian PCP pathway regulates diverse developmental processes requiring coordinated
cellular movement, including neural tube closure and cochlear stereociliary orientation…

The retinoblastoma protein (pRB) plays a key role in the control of normal development and
proliferation through the regulation of the E2F transcription factors. We generated a mutant …

Loss of cellular polarity is a hallmark of epithelial cancers, raising the possibility that regulators
of polarity have a role in suppressing tumorigenesis. The Scribble complex is one of at …

Topobiology posits that morphogenesis is driven by differential adhesive interactions
among heterogeneous cell populations. This paradigm has been revised to include force-…

Anti-cancer drug development involves enormous expenditure and risk. For rapid and
economical identification of novel, bioavailable anti-tumour chemicals, the use of appropriate in …

Asymmetric cell division is a potential means by which cell fate choices during an immune
response are orchestrated. Defining the molecular mechanisms that underlie asymmetric …

The Par complex [consisting of Bazooka (also called Par3), Par6 and aPKC] is a well-described
regulator of cell polarity whose role in many aspects of cell morphogenesis is under …

The Scribble, Par and Crumbs modules were originally identified in the vinegar (fruit) fly,
Drosophila melanogaster, as being critical regulators of apico–basal cell polarity. In the present …