The investigation into lineage allocation and early asymmetries in the pre-and peri-implantation
mouse embryo is gaining momentum. As we review here, new insights have been …

Two lines of evidence suggest that theSry-related geneSox9is important for chondrogenesis
in mammalian embryos.Sox9mRNA is expressed in chondrogenic condensations in mice, …

During early mammalian development, as the pluripotent cells that give rise to all of the tissues
of the body proliferate and expand in number, they pass through transition states marked …

We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres
by inhibiting the critical molecular pathways that predispose their differentiation. EPSCs …

The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The
primary function of gastrulation is the correct placement of precursor tissues for subsequent …

During early mouse embryogenesis, temporal and spatial regulation of gene expression and
cell signalling influences lineage specification, embryonic polarity, the patterning of tissue …

Mutations in human SOX9 are associated with campomelic dysplasia (CD), characterised
by skeletal malformation and XY sex reversal 1–3 . During chondrogenesis in the mouse, …

In the mouse, the definitive endoderm is derived from the epiblast during gastrulation, and,
at the early organogenesis stage, forms the primitive gut tube, which gives rise to the …

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused, in most classic cases,
by mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2). A large degree …

The developmental potency of cells in the proximal and distal regions of the epiblast of pre-
and early-primitive-streak-stage mouse embryos was assessed by their differentiation in the …