Rationale: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous recessive disorder
of motile cilia, but the genetic cause is not defined for all patients with PCD. Objectives: To …

Primary ciliary dyskinesia (PCD) is a genetic disorder in which impaired ciliary function
leads to chronic airway disease. Exome sequencing of a PCD subject identified an apparent …

Mucociliary clearance (MCC) is an important innate defense mechanism that continuously
removes inhaled pathogens and particulates from the airways. Normal MCC is essential for …

Mucociliary clearance, the physiological process by which mammalian conducting airways
expel pathogens and unwanted surface materials from the respiratory tract, depends on the …

Primary ciliary dyskinesia (PCD) is characterized by chronic airway disease, reduced fertility,
and randomization of the left/right body axis. It is caused by defects of motile cilia and …

Primary ciliary dyskinesia (PCD) is a rare disorder that affects the biogenesis or function of
motile cilia resulting in chronic airway disease. PCD is genetically and phenotypically …

The airway epithelial surface liquid is generally considered to be composed of two layers, a
periciliary layer and a continuous thick mucus layer moving in bulk. This view may not be …

SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell
cilia and sperm flagella. A significant number of Spag6-deficient mice die with hydrocephalus, …

Impaired mucociliary clearance (MCC) is a key feature of many airway diseases, including
asthma, bronchiectasis, chronic obstructive pulmonary disease, cystic fibrosis, and primary …

The three most important metrics in optical coherence tomography (OCT) are resolution, speed,
and sensitivity. Because there is a complex interplay between these metrics, no previous …