User profiles for Patrick S. Hume

Patrick S. Hume, MD, PhD

National Jewish Health, Denver, CO, USA
Verified email at njhealth.org
Cited by 417

Strategies to reduce dendritic cell activation through functional biomaterial design

PS Hume, J He, K Haskins, KS Anseth - Biomaterials, 2012 - Elsevier
Dendritic cells play a key role in determining adaptive immunity, and there is growing interest
in characterizing and manipulating the interactions between dendritic cells and biomaterial …

Localization of macrophages in the human lung via design-based stereology

PS Hume, SL Gibbings, CV Jakubzick… - American journal of …, 2020 - atsjournals.org
Rationale: Interstitial macrophages (IMs) and airspace macrophages (AMs) play critical roles
in lung homeostasis and host defense, and are central to the pathogenesis of a number of …

[HTML][HTML] Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury

…, B Babbs, IA Bronova, N Egersdorf, PS Hume… - JCI insight, 2023 - ncbi.nlm.nih.gov
The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing
feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear. …

Functionalized PEG hydrogels through reactive dip-coating for the formation of immunoactive barriers

PS Hume, CN Bowman, KS Anseth - Biomaterials, 2011 - Elsevier
Influencing the host immune system via implantable cell-delivery devices has the potential
to reduce inflammation at the transplant site and increase the likelihood of tissue acceptance. …

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells

…, J Roest, S Zhu, J Petersen, RP Tobin, PS Hume… - Science …, 2023 - science.org
Most human killer cell immunoglobulin-like receptors (KIR) are expressed by natural killer (NK)
cells and recognize HLA class I molecules as ligands. KIR3DL3 is a conserved but …

Inducing local T cell apoptosis with anti-Fas-functionalized polymeric coatings fabricated via surface-initiated photopolymerizations

PS Hume, KS Anseth - Biomaterials, 2010 - Elsevier
Cell encapsulation has long been investigated as a means to achieve transplant
immunoprotection as it creates a physical barrier between allograft tissue and host immune cells. …

Polymerizable superoxide dismutase mimetic protects cells encapsulated in poly (ethylene glycol) hydrogels from reactive oxygen species‐mediated damage

PS Hume, KS Anseth - … of biomedical materials research Part A, 2011 - Wiley Online Library
A polymerizable superoxide dismutase mimetic (SODm) was incorporated into poly(ethylene
glycol) (PEG) hydrogels to protect encapsulated cells from superoxide‐mediated damage. …

Spatiotemporal distribution of cellular injury and leukocytes during the progression of ventilator-induced lung injury

CL Mattson, K Okamura, PS Hume… - American Journal of …, 2022 - journals.physiology.org
Supportive mechanical ventilation is a necessary lifesaving treatment for acute respiratory
distress syndrome (ARDS). This intervention often leads to injury exacerbation by ventilator-…

[HTML][HTML] A comparison of alternative 60-mer probe designs in an in-situ synthesized oligonucleotide microarray

DL Leiske, A Karimpour-Fard, PS Hume, BD Fairbanks… - BMC genomics, 2006 - Springer
Background DNA microarrays have proven powerful for functional genomics studies. Several
technologies exist for the generation of whole-genome arrays. It is well documented that …

Hydrogel‐Embedded Precision‐Cut Lung Slices Model Lung Cancer Premalignancy Ex Vivo

…, AJ Smith, B Peña, J Driscoll, PS Hume… - Advanced …, 2024 - Wiley Online Library
Lung cancer is the leading global cause of cancer‐related deaths. Although smoking
cessation is the best prevention, 50% of lung cancer diagnoses occur in people who have quit …