User profiles for Patrick S. Hume
Patrick S. Hume, MD, PhDNational Jewish Health, Denver, CO, USA Verified email at njhealth.org Cited by 417 |
Strategies to reduce dendritic cell activation through functional biomaterial design
Dendritic cells play a key role in determining adaptive immunity, and there is growing interest
in characterizing and manipulating the interactions between dendritic cells and biomaterial …
in characterizing and manipulating the interactions between dendritic cells and biomaterial …
Localization of macrophages in the human lung via design-based stereology
PS Hume, SL Gibbings, CV Jakubzick… - American journal of …, 2020 - atsjournals.org
Rationale: Interstitial macrophages (IMs) and airspace macrophages (AMs) play critical roles
in lung homeostasis and host defense, and are central to the pathogenesis of a number of …
in lung homeostasis and host defense, and are central to the pathogenesis of a number of …
[HTML][HTML] Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury
…, B Babbs, IA Bronova, N Egersdorf, PS Hume… - JCI insight, 2023 - ncbi.nlm.nih.gov
The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing
feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear. …
feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear. …
Functionalized PEG hydrogels through reactive dip-coating for the formation of immunoactive barriers
Influencing the host immune system via implantable cell-delivery devices has the potential
to reduce inflammation at the transplant site and increase the likelihood of tissue acceptance. …
to reduce inflammation at the transplant site and increase the likelihood of tissue acceptance. …
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells
…, J Roest, S Zhu, J Petersen, RP Tobin, PS Hume… - Science …, 2023 - science.org
Most human killer cell immunoglobulin-like receptors (KIR) are expressed by natural killer (NK)
cells and recognize HLA class I molecules as ligands. KIR3DL3 is a conserved but …
cells and recognize HLA class I molecules as ligands. KIR3DL3 is a conserved but …
Inducing local T cell apoptosis with anti-Fas-functionalized polymeric coatings fabricated via surface-initiated photopolymerizations
Cell encapsulation has long been investigated as a means to achieve transplant
immunoprotection as it creates a physical barrier between allograft tissue and host immune cells. …
immunoprotection as it creates a physical barrier between allograft tissue and host immune cells. …
Polymerizable superoxide dismutase mimetic protects cells encapsulated in poly (ethylene glycol) hydrogels from reactive oxygen species‐mediated damage
A polymerizable superoxide dismutase mimetic (SODm) was incorporated into poly(ethylene
glycol) (PEG) hydrogels to protect encapsulated cells from superoxide‐mediated damage. …
glycol) (PEG) hydrogels to protect encapsulated cells from superoxide‐mediated damage. …
Spatiotemporal distribution of cellular injury and leukocytes during the progression of ventilator-induced lung injury
CL Mattson, K Okamura, PS Hume… - American Journal of …, 2022 - journals.physiology.org
Supportive mechanical ventilation is a necessary lifesaving treatment for acute respiratory
distress syndrome (ARDS). This intervention often leads to injury exacerbation by ventilator-…
distress syndrome (ARDS). This intervention often leads to injury exacerbation by ventilator-…
[HTML][HTML] A comparison of alternative 60-mer probe designs in an in-situ synthesized oligonucleotide microarray
DL Leiske, A Karimpour-Fard, PS Hume, BD Fairbanks… - BMC genomics, 2006 - Springer
Background DNA microarrays have proven powerful for functional genomics studies. Several
technologies exist for the generation of whole-genome arrays. It is well documented that …
technologies exist for the generation of whole-genome arrays. It is well documented that …
Hydrogel‐Embedded Precision‐Cut Lung Slices Model Lung Cancer Premalignancy Ex Vivo
Lung cancer is the leading global cause of cancer‐related deaths. Although smoking
cessation is the best prevention, 50% of lung cancer diagnoses occur in people who have quit …
cessation is the best prevention, 50% of lung cancer diagnoses occur in people who have quit …