[HTML][HTML] Mutational processes molding the genomes of 21 breast cancers

…, J Gamble, I Whitmore, M Maddison, PS Tarpey… - Cell, 2012 - cell.com
All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …

The landscape of cancer genes and mutational processes in breast cancer

PJ Stephens, PS Tarpey, H Davies, P Van Loo… - Nature, 2012 - nature.com
All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis …

[HTML][HTML] The life history of 21 breast cancers

…, SJ Gamble, PJ Stephens, S McLaren, PS Tarpey… - Cell, 2012 - cell.com
Cancer evolves dynamically as clonal expansions supersede one another driven by shifting
selective pressures, mutational processes, and disrupted cancer genes. These processes …

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

…, R Smith, L Stebbings, P Stephens, G Tang, PS Tarpey… - Nature, 2010 - nature.com
Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer,
characterized by the presence of inactivating mutations in the VHL gene in most cases 1 , 2 , …

What is next generation sequencing?

S Behjati, PS Tarpey - Archives of Disease in Childhood-Education and …, 2013 - ep.bmj.com
Patrick S Tarpey1 … If you wish to reuse any or all of this article please use the link below
which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to …

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

…, PS Tarpey, R Turner, K Turrell, J Varian, S West… - Nature …, 2009 - nature.com
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation
is maintained via post-translational modifications of core histones. Here, we describe …

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

S Behjati, PS Tarpey, N Presneau, S Scheipl, N Pillay… - Nature …, 2013 - nature.com
It is recognized that some mutated cancer genes contribute to the development of many
cancer types, whereas others are cancer type specific. For genes that are mutated in multiple …

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation

PS Tarpey, R Smith, E Pleasance, A Whibley… - Nature …, 2009 - nature.com
Large-scale systematic resequencing has been proposed as the key future strategy for the
discovery of rare, disease-causing sequence variants across the spectrum of human complex …

X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment

LM Dibbens, PS Tarpey, K Hynes, MA Bayly… - Nature …, 2008 - nature.com
Epilepsy and mental retardation limited to females (EFMR) is a disorder with an X-linked
mode of inheritance and an unusual expression pattern. Disorders arising from mutations on …

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

…, A Shlien, PS Tarpey, E Papaemmanuil, S Knappskog… - Science, 2014 - science.org
Introduction The human genome is peppered with mobile repetitive elements called long
interspersed nuclear element–1 (L1) retrotransposons. Propagating through RNA and cDNA …