[HTML][HTML] Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
…, N Matthews, A Stewart, P Tarpey… - New England journal …, 2012 - Mass Medical Soc
Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples. …
personalized-medicine strategies that depend on results from single tumor-biopsy samples. …
[HTML][HTML] Mutational processes molding the genomes of 21 breast cancers
…, J Gamble, I Whitmore, M Maddison, PS Tarpey… - Cell, 2012 - cell.com
All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …
DNA damage and repair processes to which cancer cells and their precursors have been …
[HTML][HTML] Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
…, AV Jones, P Guglielmelli, P Tarpey… - … England Journal of …, 2013 - Mass Medical Soc
Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative
neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with …
neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with …
The landscape of cancer genes and mutational processes in breast cancer
PJ Stephens, PS Tarpey, H Davies, P Van Loo… - Nature, 2012 - nature.com
All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis …
confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis …
[HTML][HTML] The life history of 21 breast cancers
…, SJ Gamble, PJ Stephens, S McLaren, PS Tarpey… - Cell, 2012 - cell.com
Cancer evolves dynamically as clonal expansions supersede one another driven by shifting
selective pressures, mutational processes, and disrupted cancer genes. These processes …
selective pressures, mutational processes, and disrupted cancer genes. These processes …
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
…, R Smith, L Stebbings, P Stephens, G Tang, PS Tarpey… - Nature, 2010 - nature.com
Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer,
characterized by the presence of inactivating mutations in the VHL gene in most cases 1 , 2 , …
characterized by the presence of inactivating mutations in the VHL gene in most cases 1 , 2 , …
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale …
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale …
What is next generation sequencing?
S Behjati, PS Tarpey - Archives of Disease in Childhood-Education and …, 2013 - ep.bmj.com
Next generation sequencing (NGS), massively parallel or deep sequencing are related terms
that describe a DNA sequencing technology which has revolutionised genomic research. …
that describe a DNA sequencing technology which has revolutionised genomic research. …
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
…, L Stebbings, P Stephens, G Tang, PS Tarpey… - Nature …, 2009 - nature.com
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation
is maintained via post-translational modifications of core histones. Here, we describe …
is maintained via post-translational modifications of core histones. Here, we describe …
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
It is recognized that some mutated cancer genes contribute to the development of many
cancer types, whereas others are cancer type specific. For genes that are mutated in multiple …
cancer types, whereas others are cancer type specific. For genes that are mutated in multiple …