[HTML][HTML] Intratumor heterogeneity and branched evolution revealed by multiregion sequencing

…, N Matthews, A Stewart, P Tarpey… - New England journal …, 2012 - Mass Medical Soc
Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples. …

[HTML][HTML] Mutational processes molding the genomes of 21 breast cancers

…, J Gamble, I Whitmore, M Maddison, PS Tarpey… - Cell, 2012 - cell.com
All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …

[HTML][HTML] Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

…, AV Jones, P Guglielmelli, P Tarpey… - … England Journal of …, 2013 - Mass Medical Soc
Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative
neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with …

The landscape of cancer genes and mutational processes in breast cancer

PJ Stephens, PS Tarpey, H Davies, P Van Loo… - Nature, 2012 - nature.com
All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis …

[HTML][HTML] The life history of 21 breast cancers

…, SJ Gamble, PJ Stephens, S McLaren, PS Tarpey… - Cell, 2012 - cell.com
Cancer evolves dynamically as clonal expansions supersede one another driven by shifting
selective pressures, mutational processes, and disrupted cancer genes. These processes …

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

…, R Smith, L Stebbings, P Stephens, G Tang, PS Tarpey… - Nature, 2010 - nature.com
Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer,
characterized by the presence of inactivating mutations in the VHL gene in most cases 1 , 2 , …

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

I Varela, P Tarpey, K Raine, D Huang, CK Ong… - Nature, 2011 - nature.com
The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale …

What is next generation sequencing?

S Behjati, PS Tarpey - Archives of Disease in Childhood-Education and …, 2013 - ep.bmj.com
Next generation sequencing (NGS), massively parallel or deep sequencing are related terms
that describe a DNA sequencing technology which has revolutionised genomic research. …

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

…, L Stebbings, P Stephens, G Tang, PS Tarpey… - Nature …, 2009 - nature.com
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation
is maintained via post-translational modifications of core histones. Here, we describe …

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

S Behjati, PS Tarpey, N Presneau, S Scheipl, N Pillay… - Nature …, 2013 - nature.com
It is recognized that some mutated cancer genes contribute to the development of many
cancer types, whereas others are cancer type specific. For genes that are mutated in multiple …