The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study of …

Many methods allow us to extract biological activities from omics data using information from
prior knowledge resources, reducing the dimensionality for increased statistical power and …

Extrapulmonary manifestations of COVID-19 have gained attention due to their links to clinical
outcomes and their potential long-term sequelae 1 . Severe acute respiratory syndrome …

Gene regulation plays a critical role in the cellular processes that underlie human health and
disease. The regulatory relationship between transcription factors (TFs), key regulators of …

Chemical descriptors encode the physicochemical and structural properties of small molecules,
and they are at the core of chemoinformatics. The broad release of bioactivity data has …

The Columbia Cancer Target Discovery and Development (CTD2) Center is developing
PANACEA, a resource comprising dose-responses and RNA sequencing (RNA-seq) profiles of …

Multiple sclerosis (MS) is a prototypic chronic-inflammatory disease of the central nervous
system. After initial lesion formation during active demyelination, inflammation is gradually …

Until a vaccine becomes available, the current repertoire of drugs is our only therapeutic asset
to fight the SARS-CoV-2 outbreak. Indeed, emergency clinical trials have been launched …

Impairment of the central nervous system (CNS) functions in astronauts is a major health risk
for long-duration space missions. Here, for the first time, we combine single-cell multiomics (…

Transcriptomics, and in particular RNA-Seq, has become a widely used approach to assess
the molecular state of biological systems. To facilitate its analysis, many tools have been …