To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC),
we combined single-cell RNA sequencing with spatial transcriptomics and …

CHROMATIN structure can affect the transcriptional activity of eukaryotic structural genes by
blocking access of sequence-specific activator proteins (activators) to their promoter-binding …

Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …

We present Omni-ATAC, an improved ATAC-seq protocol for chromatin accessibility
profiling that works across multiple applications with substantial improvement of signal-to-…

Several of the thousands of human long non-coding RNAs (lncRNAs) have been
functionally characterized 1 , 2 , 3 , 4 ; however, potential roles for lncRNAs in somatic tissue …

We have purified distinct complexes of nine to 12 proteins [referred to as BRG1‐associated
factors (BAFs)] from several mammalian cell lines using an antibody to the SWI2‐SNF2 …

Many systemically effective drugs such as cyclosporin A are ineffective topically because of
their poor penetration into skin. To surmount this problem, we conjugated a heptamer of …

Genome conformation is central to gene control but challenging to interrogate. Here we
present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of …

SEQUENCE-SPECIFIC DNA binding activators of gene transcription may be assisted by
SWI2(SNF2) 1,2 , which contains a DNA-depen-dent ATPase domain 3 . We have isolated a …

The retinoblastoma tumor suppressor protein (RB) binds several cellular proteins involved
in cell cycle progression. Using the yeast two-hybrid system, we found that RB bound …