User profiles for Paul A. Scheet

Paul Scheet

University of Texas MD Anderson Cancer Center
Verified email at mdanderson.org
Cited by 43832

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

…, D Zelenika, WM Chen, Y Li, LJ Scott, PA Scheet… - Nature …, 2008 - nature.com
To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals …

Single-cell transcriptomics of pancreatic cancer precursors demonstrates epithelial and microenvironmental heterogeneity as an early event in neoplastic progression

…, Y Huang, J Zhao, N Kamyabi, S Sen, PA Scheet… - Clinical Cancer …, 2019 - AACR
Purpose: Early detection of pancreatic ductal adenocarcinoma (PDAC) remains elusive.
Precursor lesions of PDAC, specifically intraductal papillary mucinous neoplasms (IPMNs), …

A genome‐wide approach to children's aggressive behavior: The EAGLE consortium

…, F Rivadeneira, A Rodriguez, PA Scheet… - American Journal of …, 2016 - Wiley Online Library
Individual differences in aggressive behavior emerge in early childhood and predict
persisting behavioral problems and disorders. Studies of antisocial and severe aggression in …

Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children

…, EA Ehli, GE Davies, PA Scheet… - Journal of the American …, 2014 - Elsevier
Objective Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by
hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. …

A genome-wide association meta-analysis of preschool internalizing problems

…, FP Velders, RK Walters, I Pappa, PA Scheet… - Journal of the American …, 2014 - Elsevier
Objective Preschool internalizing problems (INT) are highly heritable and moderately genetically
stable from childhood into adulthood. Gene-finding studies are scarce. In this study, the …

Defining the comprehensive genomic landscapes of pancreatic ductal adenocarcinoma using real-world endoscopic aspiration samples

…, BR Weston, MS Bhutani, K Chang, PA Scheet… - Clinical Cancer …, 2021 - AACR
Purpose: Most patients with pancreatic ductal adenocarcinoma (PDAC) present with surgically
unresectable cancer. As a result, endoscopic ultrasound–guided fine-needle aspiration (…

Augmented lipocalin-2 is associated with chronic obstructive pulmonary disease and counteracts lung adenocarcinoma development

…, II Wistuba, SJ Moghaddam, PA Scheet… - American journal of …, 2021 - atsjournals.org
Rationale: Early pathogenesis of lung adenocarcinoma (LUAD) remains largely unknown.
We found that, relative to wild-type littermates, the innate immunomodulator Lcn2 (lipocalin-2) …

Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study

…, V Ravi, L Russell, B Sajith, PA Scheet… - Cancer …, 2023 - Wiley Online Library
Introduction Survivors of SARS‐CoV‐2 pneumonia often develop persistent respiratory symptom
and interstitial lung abnormalities (ILAs) after infection. Risk factors for ILA development …

Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis

…, PM Lynch, C Lazaro, NE Navin, PA Scheet… - Clinical Cancer …, 2017 - AACR
Purpose: The majority of genomic alterations causing intratumoral heterogeneity (ITH) in
colorectal cancer are thought to arise during early stages of carcinogenesis as a burst but only …

A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems

…, GE Davies, EA Ehli, X Xiao, PA Scheet… - American Journal of …, 2013 - Wiley Online Library
Breastfeeding has been associated with improved cognitive functioning. There is a beneficial
effect on IQ, and possibly on associated phenotypes such as attention problems. It has …