The most common reported reasons for intensive care unit admission for patients with severe
coronavirus disease 2019 (COVID-19) are either hypoxemic respiratory failure leading to …

Hypertension places a major burden on individual and public health, but the genetic basis
of this complex disorder is poorly understood. We conducted a genome-wide association …

Diabetic nephropathy is characterized by damage to both the glomerulus and tubulointerstitium,
but relatively little is known about accompanying cell-specific changes in gene …

The discovery of the renal outer medullary K + channel (ROMK, K ir 1.1), the founding member
of the inward-rectifying K + channel (K ir ) family, by Ho and Hebert in 1993 revolutionized …

The Kir1.1 (ROMK) subtypes of inward rectifier K + channels mediate potassium secretion
and regulate sodium chloride reabsorption in the kidney. The density of ROMK channels on …

Aberrant activation of with no lysine (WNK) kinases causes familial hyperkalemic hypertension
(FHHt). Thiazide diuretics treat the disease, fostering the view that hyperactivation of the …

STE20/SPS-1-related proline-alanine-rich protein kinase (SPAK) and oxidative stress-related
kinase (OSR1) activate the potassium-dependent sodium-chloride co-transporter, NKCC2, …

Consumption of low dietary potassium, common with ultraprocessed foods, activates the
thiazide-sensitive sodium chloride cotransporter (NCC) via the with no (K) lysine kinase/STE20/…

Mechanisms that are responsible for sorting newly synthesized proteins for traffic to the cell
surface from the Golgi are poorly understood. Here, we show that the potassium channel Kir2.…

More than two dozen types of potassium channels, with different biophysical and regulatory
properties, are expressed in the kidney, influencing renal function in many important ways. …