Molecular dating of species divergences has become an important means to add a temporal
dimension to the Tree of Life. Increasingly larger datasets encompassing greater taxonomic …

Many complex human diseases are highly sexually dimorphic, suggesting a potential
contribution of the X chromosome to disease risk. However, the X chromosome has been …

Background Mitochondrial dysfunction has been hypothesized to occur in Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a disease characterized by fatigue, …

We present a procedure to test the effect of calibration priors on estimated times, which applies
a recently developed calibration-free approach (RelTime) method that produces relative …

The Bene Israel Jewish community from West India is a unique population whose history
before the 18 th century remains largely unknown. Bene Israel members consider themselves …

Phylogenetic analyses are using increasingly larger data sets for estimating divergence times.
With this increase in data sizes, the computation time required is becoming a bottleneck in …

Background A central problem of computational metagenomics is determining the correct
placement into an existing phylogenetic tree of individual reads (nucleotide sequences of …

The determinants of severe COVID-19 in non-elderly adults are poorly understood, which
limits opportunities for early intervention and treatment. Here we present novel machine …

Earlier this year, we described an analysis of mitochondrial DNA (mtDNA) variants in myalgic
encephalomyelitis (ME)/chronic fatigue syndrome (CFS) patients and healthy controls. We …

Biomedical studies have become larger in size and yielded large quantities of data, yet
efficient data processing remains a challenge. Here we present Trellis, a cloud-based data and …