User profiles for Paul Charlesworth

Paul Charlesworth

Michigan Technological University
Verified email at mtu.edu
Cited by 764

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

M Migaud, P Charlesworth, M Dempster, LC Webster… - Nature, 1998 - nature.com
Specific patterns of neuronal firing induce changes in synaptic strength that may contribute
to learning and memory. If the postsynaptic NMDA (N-methyl-D-aspartate) receptors are …

SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor

…, HJ Carlisle, K Porter, P Charlesworth… - Journal of …, 2002 - Soc Neuroscience
At excitatory synapses, the postsynaptic scaffolding protein postsynaptic density 95 (PSD-95)
couples NMDA receptors (NMDARs) to the Ras GTPase-activating protein SynGAP. The …

Photophysical properties of 5, 10, 15, 20-tetrakis (m-hydroxyphenyl) porphyrin (m-THPP), 5, 10, 15, 20-tetrakis (m-hydroxyphenyl) chlorin (m-THPC) and 5, 10, 15, 20 …

R Bonnett, P Charlesworth, BD Djelal… - Journal of the …, 1999 - pubs.rsc.org
For the tumour photosensitisers m-THPP, m-THPC, and m-THPBC in methanol the following
photophysical properties have been measured: absorption and fluorescence spectra, ES, …

[HTML][HTML] Emergence of rich-club topology and coordinated dynamics in development of hippocampal functional networks in vitro

MS Schroeter, P Charlesworth… - Journal of …, 2015 - Soc Neuroscience
Recent studies demonstrated that the anatomical network of the human brain shows a “rich-club”
organization. This complex topological feature implies that highly connected regions, …

[HTML][HTML] A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks

E Cotterill, P Charlesworth… - Journal of …, 2016 - journals.physiology.org
Accurate identification of bursting activity is an essential element in the characterization of
neuronal network activity. Despite this, no one technique for identifying bursts in spike trains …

[HTML][HTML] Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures

P Charlesworth, E Cotterill, A Morton, SGN Grant… - Neural …, 2015 - Springer
Background Neural circuits can spontaneously generate complex spatiotemporal firing patterns
during development. This spontaneous activity is thought to help guide development of …

[HTML][HTML] Is early delivery beneficial in gastroschisis?

…, S Pereira, CP James, PB Charlesworth… - Journal of pediatric …, 2014 - Elsevier
Purpose Gastroschisis neonates have delayed time to full enteral feeds (ENT), possibly due
to bowel exposure to amniotic fluid. We investigated whether delivery at < 37 weeks …

[PDF][PDF] Developing 3 D spatial visualization skills for non engineering students

…, T Drummer, K Hungwe, P Charlesworth - 2005 Annual …, 2005 - peer.asee.org
The ability to visualize objects and situations in one’s mind and to manipulate those images
is a cognitive skill vital to many career fields, especially those requiring work with graphical …

[HTML][HTML] Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro

EJ MacLaren, P Charlesworth, MP Coba… - Molecular and Cellular …, 2011 - Elsevier
Schizophrenia and bipolar disorder are common diseases caused by multiple genes that
disrupt brain circuits. While great progress has been made in identifying schizophrenia …

Postnatal outcome in gastroschisis: effect of birth weight and gestational age

P Charlesworth, I Njere, J Allotey, G Dimitrou… - Journal of pediatric …, 2007 - Elsevier
INTRODUCTION: Early elective delivery of antenatally diagnosed gastroschisis has been
proposed as a strategy to minimize postnatal morbidity. This hypothesis was tested by …