We aimed to estimate the global occurrence of zoonotic tuberculosis (TB) caused by
Mycobacterium bovis or M. caprae infections in humans by performing a multilingual, systematic …

Anti-tuberculosis drugs are a two-edged sword. While they destroy pathogenic M. tuberculosis
they also select for drug resistant bacteria against which those drugs are then ineffective. …

Numerous studies have reported that individuals can simultaneously harbor multiple distinct
strains of Mycobacterium tuberculosis . To date, there has been limited discussion of the …

Background The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a
member of the CRISPR (Clustered regularly interspaced short palindromic repeats) …

Background For decades it has been assumed that postprimary tuberculosis is usually
caused by reactivation of endogenous infection rather than by a new, exogenous infection. …

Rationale: In a high–tuberculosis (TB) incidence area of Cape Town, South Africa, there is a
very high rate of unexplained recurrent TB. The incidence of new bacteriologically …

Background The PE and PPE multigene families of Mycobacterium tuberculosis comprise
about 10% of the coding potential of the genome. The function of the proteins encoded by …

The prevalence of infection among household contacts of people with tuberculosis is high.
This information frequently guides active case finding. We analysed DNA fingerprints of …

It is generally accepted that tuberculosis results from a single infection with a single Mycobacterium
tuberculosis strain. Such infections are thought to confer protective immunity against …

Seven outbreaks involving increasing numbers of banded mongoose troops and high death
rates have been documented. We identified a Mycobacterium tuberculosis complex …