Genomic imprinting is an epigenetic modification that results in expression from only one of
the two parental copies of a gene. Differences in methylation between the two parental …

Matrix metalloproteinases (MMPs) are synthesized as latent proenzymes. A proteolytic
cleavage event involving processing of the cysteine-rich N-terminal propeptide is required for …

Genomic imprinting causes parental origin–specific monoallelic gene expression through
differential DNA methylation established in the parental germ line. However, the mechanisms …

Imprinted genes display differential allelic expression in a manner that depends on the sex
of the transmitting parent. The degree of imprinting is often tissue-specific and/or …

Rationale: Myocardial infarction (MI) results in remodeling of the myocardium and the extracellular
matrix (ECM). Tissue inhibitors of metalloproteinases (TIMPs) are critical regulators of …

The role of membrane-type (MT) 2-matrix metalloproteinase (MMP) in the cellular activation
of MMP-2 and the tissue inhibitor of matrix metalloproteinase (TIMP) requirements for this …

It is well known that a variety of genetic changes influence the development and progression
of cancer. These changes may result from inherited or spontaneous mutations that are not …

Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene
regulation. Studies conducted over a decade ago revealed that maturation of spliced, …

The membrane type (MT)-matrix metalloproteinases (MMPs) constitute a subgroup of
membrane-anchored MMPs that are major mediators of pericellular proteolysis and physiological …

Liver regeneration depends on timely restoration of cellular mass while orchestrating structural
matrix remodeling. Matrix metalloproteinases (MMPs) and their endogenous inhibitors (…