Integration of human papillomavirus type 16 (HPV-16) DNA into a host chromosome has been
hypothesized to result in altered expression of two viral transforming genes, E6 and E7, in …

In many cervical cancers, human papillomavirus type 16 (HPV-16) DNA genomes are found
to be integrated into the host chromosome. In this study, we demonstrate that integration of …

Background: A recent review by the International Agency for Research on Cancer (IARC)
updated the assessments of the > 100 agents classified as Group 1, carcinogenic to humans (…

p53 exerts its cell cycle regulatory effects through its ability to function as a sequence-specific
DNA binding transcription factor. CREB-binding protein (CBP)/p300, through its interaction …

Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30%
of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV-…

Human papillomaviruses (HPVs) are DNA viruses associated with major human cancers. As
such there is a strong interest in developing new means, such as vaccines and microbicides…

Patients with human papillomavirus (HPV+)–associated head and neck cancer (HNC) show
significantly improved survival outcome compared with those with HPV-negative (HPV−) …

Human cervix cancer is caused by high-risk human papillomaviruses encoding E6 and E7
oncoproteins, each of which alter function of distinct targets regulating the cell cycle, apoptosis…

High-risk human papillomaviruses (HPVs) are the causative agents of certain human
cancers. HPV type 16 (HPV16) is the papillomavirus most frequently associated with cervical …

The human papillomavirus type 16 (HPV-16) genome is commonly present in human
cervical carcinoma, in which a subset of the viral genes, E6 and E7, are expressed. The HPV-16 …