Signalling by Wnt proteins is finely balanced to ensure normal development and tissue
homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly …

Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell
competition, cells with a heterozygous mutation in ribosome genes, such as RpS3 +/− cells, …

Wnt proteins activate a conserved signalling pathway that controls development and tissue
homeostasis in all metazoans. The intensity of Wnt signalling must be tightly controlled to …

Cell competition induces the elimination of less-fit “loser” cells by fitter “winner” cells. In
Drosophila, cells heterozygous mutant in ribosome genes, Rp/+, known as Minutes, are …

Investigating organ biology often requires methodologies to induce genetically distinct
clones within a living tissue. However, the 3D nature of clones makes sample image analysis …

Src-family kinases (SFKs) control a variety of biological processes, from cell proliferation
and differentiation to cytoskeletal rearrangements. Abnormal activation of SFKs has been …

Background Adherens junctions (AJs) provide structure to epithelial tissues by connecting
adjacent cells through homophilic E-cadherin interactions and are linked to the actin …

The coordinated polarization of cells in the plane of a tissue, termed planar polarity, is a
characteristic feature of epithelial tissues [1]. In the fly wing, trichome positioning is dependent …

Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved
in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling …

Epithelial homeostasis and the avoidance of diseases such as cancer require the elimination
of defective cells by apoptosis. Here, we investigate how loss of apical determinants …