Structural basis of purine nucleotide inhibition of human uncoupling protein 1

…, DM Copeman, CA Cotrim, J Steyaert, PG Crichton… - Science …, 2023 - science.org
Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its
specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, …

[PDF][PDF] The molecular mechanism of transport by the mitochondrial ADP/ATP carrier

…, T Zögg, AA Aleksandrova, E Pardon, PG Crichton… - Cell, 2019 - cell.com
Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP synthesis,
and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix-open states. …

Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism

…, M Harding, PG Crichton… - Proceedings of the …, 2014 - National Acad Sciences
The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the
mitochondrial matrix. The carrier cycles by an unresolved mechanism between the …

Function of the alternative oxidase: is it still a scavenger?

AL Moore, MS Albury, PG Crichton, C Affourtit - Trends in Plant Science, 2002 - cell.com
The alternative oxidase is a respiratory chain protein found in all higher plants, fungi, non-fermentative
yeasts and trypanosomes. Its primary structure suggests that it is a new member …

[HTML][HTML] The transport mechanism of the mitochondrial ADP/ATP carrier

…, M Kibalchenko, S Tavoulari, PG Crichton… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the
mitochondrial matrix, which are key transport steps for oxidative phosphorylation in …

[HTML][HTML] The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism

PG Crichton, Y Lee, ERS Kunji - Biochimie, 2017 - Elsevier
Uncoupling protein 1 (UCP1) is an integral membrane protein found in the mitochondrial
inner membrane of brown adipose tissue, and facilitates the process of non-shivering …

[HTML][HTML] Exploring the molecular nature of alternative oxidase regulation and catalysis

C Affourtit, MS Albury, PG Crichton, AL Moore - FEBS letters, 2002 - Elsevier
Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the
oxidation of ubiquinol to the complete reduction of oxygen to water. In this paper we review …

Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin

…, ERS Kunji, PG Crichton - Proceedings of the …, 2015 - National Acad Sciences
Uncoupling protein 1 (UCP1) catalyzes fatty acid-activated, purine nucleotide-sensitive proton
leak across the mitochondrial inner membrane of brown adipose tissue to produce heat, …

[HTML][HTML] Mitochondrial carriers function as monomers

ERS Kunji, PG Crichton - Biochimica et Biophysica Acta (BBA) …, 2010 - Elsevier
Mitochondrial carriers link biochemical pathways in the mitochondrial matrix and cytosol by
transporting metabolites, inorganic ions, nucleotides, and cofactors across the mitochondrial …

[HTML][HTML] Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier

MS King, M Kerr, PG Crichton, R Springett… - Biochimica et Biophysica …, 2016 - Elsevier
Mitochondrial ADP/ATP carriers catalyze the equimolar exchange of ADP and ATP across
the mitochondrial inner membrane. Structurally, they consist of three homologous domains …