User profiles for Paul Gontarz
 | Paul GontarzWashington University School of Medicine Verified email at wustl.edu Cited by 740 |
Derivation of trophoblast stem cells from naïve human pluripotent stem cells
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell
fate decisions during pre-implantation development, but their lineage potential remains …
fate decisions during pre-implantation development, but their lineage potential remains …
[HTML][HTML] Tissue-specific usage of transposable element-derived promoters in mouse development
Background Transposable elements (TEs) are a significant component of eukaryotic genomes
and play essential roles in genome evolution. Mounting evidence indicates that TEs are …
and play essential roles in genome evolution. Mounting evidence indicates that TEs are …
[PDF][PDF] Deconstructing stepwise fate conversion of human fibroblasts to neurons by microRNAs
Cell-fate conversion generally requires reprogramming effectors to both introduce fate
programs of the target cell type and erase the identity of starting cell population. Here, we reveal …
programs of the target cell type and erase the identity of starting cell population. Here, we reveal …
[PDF][PDF] The Reissner fiber is highly dynamic in vivo and controls morphogenesis of the spine
Cerebrospinal fluid (CSF) physiology is important for the development and homeostasis of
the central nervous system, and its disruption has been linked to scoliosis in zebrafish [1, 2]. …
the central nervous system, and its disruption has been linked to scoliosis in zebrafish [1, 2]. …
Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis
The histone demethylase KDM6B (JMJD3) is upregulated in blood disorders, suggesting
that it may have important pathogenic functions. Here we examined the function of Kdm6b in …
that it may have important pathogenic functions. Here we examined the function of Kdm6b in …
[HTML][HTML] OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal
maintenance and application of embryonic stem cells (ESCs). While the protein-protein …
maintenance and application of embryonic stem cells (ESCs). While the protein-protein …
[HTML][HTML] Comparison of differential accessibility analysis strategies for ATAC-seq data
ATAC-seq is widely used to measure chromatin accessibility and identify open chromatin
regions (OCRs). OCRs usually indicate active regulatory elements in the genome and are …
regions (OCRs). OCRs usually indicate active regulatory elements in the genome and are …
Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice
…, JA McKenzie, EG Buettmann, X Liu, PM Gontarz… - Bone, 2019 - Elsevier
Bone fracture repair represents an important clinical challenge with nearly 1 million non-union
fractures occurring annually in the US Gene expression differs between non-union and …
fractures occurring annually in the US Gene expression differs between non-union and …
Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development
K Meganathan, EMA Lewis, P Gontarz… - Proceedings of the …, 2017 - National Acad Sciences
Cortical interneurons (cINs) modulate excitatory neuronal activity by providing local
inhibition. During fetal development, several cIN subtypes derive from the medial ganglionic …
inhibition. During fetal development, several cIN subtypes derive from the medial ganglionic …
AIAP: a quality control and integrative analysis package to improve ATAC-seq data analysis
Assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq)
is a technique widely used to investigate genome-wide chromatin accessibility. The recently …
is a technique widely used to investigate genome-wide chromatin accessibility. The recently …