Glioblastoma multiforme (GBM) is the most aggressive brain tumor in adults and remains
incurable despite multimodal intensive treatment regimens. EGFRvIII is a truncated …

The epidermal growth factor receptor (EGFR) is a primary contributor to glioblastoma (GBM)
initiation and progression. Here, we examine how EGFR and key downstream signaling …

Epidermal growth factor receptor (EGFR) mutations are the second most common oncogenic
driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 …

Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor
(EGFR) gene were among the first EGFR mutations to be identified as oncogenic drivers …

14-3-3 proteins are crucial in a wide variety of cellular responses including cell cycle
progression, DNA damage checkpoints and apoptosis. One particular 14-3-3 isoform, σ, is a p53-…

Liposarcomas are rare malignant tumors of adipocytic differentiation. The classification of
liposarcomas into four principal subtypes reflects the distinct clinical behavior, treatment …

Data-independent acquisition mass spectrometry (DIA-MS) is a next generation proteomic
methodology that generates permanent digital proteome maps offering highly reproducible …

Cancer cells employ multiple mechanisms to evade tightly regulated cellular processes
such as proliferation, apoptosis, and senescence. Systems-wide analyses of tumors have …

Osteosarcoma is the most common primary bone sarcoma and is often diagnosed in the 2nd–3rd
decades of life. Response to the aggressive and highly toxic neoadjuvant methotrexate…

Malignant gliomas are characterized by a diffuse infiltration into the surrounding brain
parenchyma. Infiltrating glioma cells exist in close proximity with components of the tumor …