User profiles for Paul Kievit
 | Paul KievitAssistant Professor, OHSU Verified email at ohsu.edu Cited by 2218 |
Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese …
The melanocortin-4 receptor (MC4R) is well recognized as an important mediator of body
weight homeostasis. Activation of MC4R causes dramatic weight loss in rodent models, and …
weight homeostasis. Activation of MC4R causes dramatic weight loss in rodent models, and …
Maternal high‐fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring
HM Rivera, P Kievit, MA Kirigiti, LA Bauman… - …, 2015 - Wiley Online Library
Objective To utilize a nonhuman primate model to examine the impact of maternal high‐fat
diet (HFD) consumption and pre‐pregnancy obesity on offspring intake of palatable food and …
diet (HFD) consumption and pre‐pregnancy obesity on offspring intake of palatable food and …
Proinflammatory endothelial activation detected by molecular imaging in obese nonhuman primates coincides with onset of insulin resistance and progressively …
…, JT Belcik, L Bader, MA Kirigiti, DM Peters, P Kievit… - Circulation, 2014 - Am Heart Assoc
Background— Inflammation and insulin resistance (IR) are associated processes that
potentiate risk for cardiovascular disease in obesity. The temporal relation between IR and …
potentiate risk for cardiovascular disease in obesity. The temporal relation between IR and …
[HTML][HTML] Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques
…, C Gattis, R Basco, JR Millman, P Kievit… - Nature …, 2024 - nature.com
Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a recipient’s
immune system would abolish the requirement for immunosuppressive drugs or …
immune system would abolish the requirement for immunosuppressive drugs or …
[PDF][PDF] Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
P Kievit, JK Howard, MK Badman, N Balthasar… - Cell metabolism, 2006 - cell.com
Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various
cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of …
cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of …
[HTML][HTML] Regulated production of a peroxisome proliferator-activated receptor-γ ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes
Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear hormone receptor that is
critical for adipogenesis and insulin sensitivity. Ligands for PPARγ include some …
critical for adipogenesis and insulin sensitivity. Ligands for PPARγ include some …
[HTML][HTML] Early high-fat diet exposure causes dysregulation of the orexin and dopamine neuronal populations in nonhuman primates
…, S Lindsley, M Kirigiti, E Sullivan, P Kievit - Frontiers in …, 2018 - frontiersin.org
Maternal obesity and consumption of a high-fat diet (HFD) during pregnancy has a negative
impact on offspring, including an increased risk for the development of obesity in …
impact on offspring, including an increased risk for the development of obesity in …
[HTML][HTML] Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models
…, RJ Seeley, DP Olson, P Kievit… - The Journal of …, 2023 - Am Soc Clin Investig
The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control
energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb …
energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb …
[PDF][PDF] Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring
Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal
offspring. This constitutes a major public health concern due to increasing prevalence of these …
offspring. This constitutes a major public health concern due to increasing prevalence of these …
Use and importance of nonhuman primates in metabolic disease research: current state of the field
Obesity and its multiple metabolic sequelae, including type 2 diabetes, cardiovascular disease,
and fatty liver disease, are becoming increasingly widespread in both the developed and …
and fatty liver disease, are becoming increasingly widespread in both the developed and …