[HTML][HTML] Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private–public partnership
between the UK Biobank (UKB) and eight biopharmaceutical companies that will complete …
between the UK Biobank (UKB) and eight biopharmaceutical companies that will complete …
[HTML][HTML] The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
T Nguyen, P Nioi, CB Pickett - Journal of biological chemistry, 2009 - ASBMB
A major mechanism in the cellular defense against oxidative or electrophilic stress is
activation of the Nrf2-antioxidant response element signaling pathway, which controls the …
activation of the Nrf2-antioxidant response element signaling pathway, which controls the …
The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
P Nioi, T Nguyen, PJ Sherratt… - Molecular and cellular …, 2005 - Taylor & Francis
Nrf2 is a transcription factor critical for the maintenance of cellular redox homeostasis. We
have previously found that Nrf2 is a labile protein, and its activation in cells under stress …
have previously found that Nrf2 is a labile protein, and its activation in cells under stress …
Contribution of NAD (P) H: quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the …
P Nioi, JD Hayes - … Research/Fundamental and Molecular Mechanisms of …, 2004 - Elsevier
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against
reactive forms of oxygen and inhibition of neoplasia. Under conditions of oxidative stress, …
reactive forms of oxygen and inhibition of neoplasia. Under conditions of oxidative stress, …
[HTML][HTML] Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease
P Nioi, A Sigurdsson, G Thorleifsson… - … England Journal of …, 2016 - Mass Medical Soc
Background Several sequence variants are known to have effects on serum levels of non–high-density
lipoprotein (HDL) cholesterol that alter the risk of coronary artery disease. …
lipoprotein (HDL) cholesterol that alter the risk of coronary artery disease. …
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD (P) H: quinone oxidoreductase 1 gene: reassessment of the ARE …
P Nioi, M McMahon, K Itoh, M Yamamoto… - Biochemical …, 2003 - portlandpress.com
NQO1 [NAD(P)H:quinone oxidoreductase 1] has an integral role in cellular responses to
oxidative stress. The expression of NQO1 is up-regulated in the mouse following challenge with …
oxidative stress. The expression of NQO1 is up-regulated in the mouse following challenge with …
[HTML][HTML] Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1
T Nguyen, PJ Sherratt, P Nioi, CS Yang… - Journal of Biological …, 2005 - ASBMB
Nrf2 regulates the expression of genes encoding antioxidant proteins involved in cellular
redox homeostasis. Previous studies have suggested that activation of Nrf2 is mediated by …
redox homeostasis. Previous studies have suggested that activation of Nrf2 is mediated by …
[PDF][PDF] Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
…, Y Huang, E Kvikstad, A O'Neill, P Nioi… - The American Journal of …, 2021 - cell.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease
2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used …
2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used …
Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants
The UK Biobank Pharma Proteomics Project (UKB-PPP) is a collaboration between the UK
Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma …
Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma …
[HTML][HTML] Plasma proteomic associations with genetics and health in the UK Biobank
…, JMM Howson, HM Kang, MI McCarthy, P Nioi… - Nature, 2023 - nature.com
The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing
the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a …
the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a …