Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting
millions of people worldwide and ranking as a leading cause of disability for almost three …

We present a large-scale analysis of mRNA coexpression based on 60 large human data
sets containing a total of 3924 microarrays. We sought pairs of genes that were reliably …

The hyperpolarization-activated cation current (termedI h ,I q , orI f ) was recently shown to
be encoded by a new family of genes, named HCN forhyperpolarization-activated …

Individuals with 22q11.2 microdeletions show behavioral and cognitive deficits and are at
high risk of developing schizophrenia. We analyzed an engineered mouse strain carrying a …

Genomic imprinting is an epigenetic mechanism of regulation that restrains the expression
of a small subset of mammalian genes to one parental allele. The reason for the targeting of …

Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …

We describe a simple software tool, ‘matrix2png’, for creating color images of matrix data.
Originally designed with the display of microarray data sets in mind, it is a general tool that can …

In our attempts to understand cellular function at the molecular level, we must be able to
synthesize information from disparate types of genomic data. We consider the problem of …

Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic etiology.
Recent studies of de novo mutations (DNMs) in schizophrenia and autism have reinforced …

In our attempts to understand cellular function at the molecular level, we must be able to
synthesize information from disparate types of genomic data. We consider the problem of …