Lysobacter enzymogenes C3 is a predatory strain of Gram-negative gliding bacteria that
produces antifungal antibiotics by the polyketide synthetic pathway. Outer membrane vesicles (…

Although Ca 2+ is involved in many biological membrane fusion phenomena, the mechanism
of its action is not well understood. It could participate directly in the fusion reaction by …

Membranes provide the barrier of cellular individuality or intracellular compartmentation.
Individuality or compartmentation is unlikely to be traversed except in A. well-regulated …

Dimyristoyl phosphatidylcholine was prepared with perdeuterated hydrocarbon chains and
sonicated into bilayer vesicles together with gramicidin A′. The 1 H NMR resonance from …

Small molecule antibiotics are often derived from microorganisms that thrive in competitive
environments. Their importance as therapeutics for infectious disease in humans has been …

Liposomes represent the lipid bilayer backbone of biological membranes and have been
used extensively as a model system to study the fusion of biological membranes (1). Early …

Liposomes represent one of the first “nanoscale” technologies used in drug delivery, and
continue to be a source of innovative solutions because of the vast variety of lipid compositions, …

Gram negative bacteria produce small∼ 50-200 nm vesicles from their outer membranes.
These outer membrane vesicles (OMV) have been implicated in activities such as …

90a Sunday, February 3, 2013 the design of liposomes for fusogenic delivery to OMV targets.
There is therapeutic interest in delivery to Gram-negative OMV, eg where they exist in …

Endogenous retroviruses are a common ancestral feature of mammalian genomes with most
having been inactivated over time through mutation and deletion 1 . A group of more intact …