[HTML][HTML] Endothelial dysfunction in heart failure with preserved ejection fraction: what are the experimental proofs?
L Cornuault, P Rouault, C Duplàa, T Couffinhal… - Frontiers in …, 2022 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) has been recognized as the greatest
single unmet need in cardiovascular medicine. Indeed, the morbi-mortality of HFpEF is high …
single unmet need in cardiovascular medicine. Indeed, the morbi-mortality of HFpEF is high …
Praliciguat promotes ischemic leg reperfusion in leptin receptor-deficient mice
N Foussard, P Rouault, L Cornuault… - Circulation …, 2023 - Am Heart Assoc
Background: Lower-limb peripheral artery disease is one of the major complications of
diabetes. Peripheral artery disease is associated with poor limb and cardiovascular prognoses, …
diabetes. Peripheral artery disease is associated with poor limb and cardiovascular prognoses, …
Mast cells are the trigger of small vessel disease and diastolic dysfunction in diabetic obese mice
S Guimbal, L Cornuault, P Rouault… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Heart failure with preserved ejection fraction is a major health care issue which
has been difficult to manage to date, due to its complex and not well understood …
has been difficult to manage to date, due to its complex and not well understood …
Thrombosis in the Coronary Microvasculature Impairs Cardiac Relaxation and Induces Diastolic Dysfunction
P Rouault, S Guimbal, L Cornuault… - … and Vascular Biology, 2024 - Am Heart Assoc
BACKGROUND: Heart failure with preserved ejection fraction is proposed to be caused by
endothelial dysfunction in cardiac microvessels. Our goal was to identify molecular and …
endothelial dysfunction in cardiac microvessels. Our goal was to identify molecular and …
Partial mural cell ablation disrupts coronary vasculature integrity and induces systolic dysfunction
…, FX Hérion, C Bourguignon, P Rouault… - Journal of the …, 2023 - Am Heart Assoc
Background Although the critical role of pericytes in maintaining vascular integrity has been
extensively demonstrated in the brain and the retina, little is known about their role in the …
extensively demonstrated in the brain and the retina, little is known about their role in the …
Juxtacrine DLL4-NOTCH1 signaling between astrocytes drives neuroinflammation via the IL-6-STAT3 axis
P Mora, M Laisne, C Bourguignon, P Rouault… - bioRxiv, 2023 - biorxiv.org
Under neuroinflammatory conditions, astrocytes acquire a reactive phenotype that drives
acute inflammatory injury as well as chronic neurodegeneration. We hypothesized that …
acute inflammatory injury as well as chronic neurodegeneration. We hypothesized that …
Cardiac pericytes are necessary for coronary vasculature integrity and cardiomyocyte differentiation
L Cornuault, FX Hérion, P Rouault, N Foussard… - bioRxiv, 2022 - biorxiv.org
Introduction: While the critical role of pericytes in maintaining vascular integrity has been
extensively demonstrated in the brain and in the retina, very little is known about their role in the …
extensively demonstrated in the brain and in the retina, very little is known about their role in the …
Increased endothelium activation and leakage do not promote diastolic dysfunction in mice fed with a high fat diet and treated with L-NAME
L Cornuault, P Mora, P Rouault, N Foussard… - bioRxiv, 2023 - biorxiv.org
Coronary microvascular disease has been proposed to be responsible for heart failure with
preserved ejection fraction (HFpEF) about 10 years ago. However, to date the role and …
preserved ejection fraction (HFpEF) about 10 years ago. However, to date the role and …
Abstract P3107: Sexual Dimorphism In Diastolic Dysfunction And Cardiac Small Vessel Disease In Heart Failure With Preserved Ejection Fraction Mouse Models
L Cornuault, V Grouthier, P Rouault… - Circulation …, 2023 - Am Heart Assoc
Introduction: Coronary microvascular disease has been proposed to be responsible for heart
failure with preserved ejection fraction (HFpEF) about 10 years ago. However, to date the …
failure with preserved ejection fraction (HFpEF) about 10 years ago. However, to date the …
Thrombosis in the coronary microvasculature may be responsible for impaired cardiac relaxation and diastolic dysfunction
P Rouault, S Guimbal, L Cornuault… - European Heart …, 2023 - academic.oup.com
Introduction Heart Failure with Preserved Ejection Fraction (HFpEF) is proposed to be caused
by endothelial dysfunction in cardiac small vessels. We previously identified Hhipl1,as a …
by endothelial dysfunction in cardiac small vessels. We previously identified Hhipl1,as a …