User profiles for Paul Ryvkin
 | Paul Ryvkin10X Genomics, Inc. Verified email at paulryvkin.com Cited by 8072 |
[HTML][HTML] Massively parallel digital transcriptional profiling of single cells
Characterizing the transcriptome of individual cells is fundamental to understanding complex
biological systems. We describe a droplet-based system that enables 3′ mRNA counting …
biological systems. We describe a droplet-based system that enables 3′ mRNA counting …
Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the
WRN and BLM RecQ helicases, respectively. WRN, BLM and their Saccharomyces cerevisiae …
WRN and BLM RecQ helicases, respectively. WRN, BLM and their Saccharomyces cerevisiae …
[HTML][HTML] Genome-Wide Double-Stranded RNA Sequencing Reveals the Functional Significance of Base-Paired RNAs in Arabidopsis
The functional structure of all biologically active molecules is dependent on intra- and inter-molecular
interactions. This is especially evident for RNA molecules whose functionality, …
interactions. This is especially evident for RNA molecules whose functionality, …
[PDF][PDF] Global analysis of RNA secondary structure in two metazoans
The secondary structure of RNA is necessary for its maturation, regulation, processing, and
function. However, the global influence of RNA folding in eukaryotes is still unclear. Here, we …
function. However, the global influence of RNA folding in eukaryotes is still unclear. Here, we …
HAMR: high-throughput annotation of modified ribonucleotides
RNA is often altered post-transcriptionally by the covalent modification of particular nucleotides;
these modifications are known to modulate the structure and activity of their host RNAs. …
these modifications are known to modulate the structure and activity of their host RNAs. …
[HTML][HTML] Microarray-based cell-free DNA analysis improves noninvasive prenatal testing
Objective: To develop a microarray-based method for noninvasive prenatal testing (NIPT)
and compare it with next-generation sequencing. Methods: Maternal plasma from 878 …
and compare it with next-generation sequencing. Methods: Maternal plasma from 878 …
Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence
Cellular senescence is accompanied by dramatic changes in chromatin structure and gene
expression. Using Saccharomyces cerevisiae mutants lacking telomerase (tlc1Δ) to model …
expression. Using Saccharomyces cerevisiae mutants lacking telomerase (tlc1Δ) to model …
[HTML][HTML] Transcriptomic changes due to cytoplasmic TDP-43 expression reveal dysregulation of histone transcripts and nuclear chromatin
A Amlie-Wolf, P Ryvkin, R Tong, I Dragomir, ER Suh… - PLoS …, 2015 - journals.plos.org
TAR DNA-binding protein 43 (TDP-43) is normally a nuclear RNA-binding protein that exhibits
a range of functions including regulation of alternative splicing, RNA trafficking, and RNA …
a range of functions including regulation of alternative splicing, RNA trafficking, and RNA …
CoRAL: predicting non-coding RNAs from small RNA-sequencing data
The surprising observation that virtually the entire human genome is transcribed means we
know little about the function of many emerging classes of RNAs, except their astounding …
know little about the function of many emerging classes of RNAs, except their astounding …
Computational detection and analysis of sequences with duplex-derived interstrand G-quadruplex forming potential
Bioinformatic approaches to the identification of genomic sequences having G-quadruplex
forming potential (QFP) has enabled important tests of the structure of these sequences in …
forming potential (QFP) has enabled important tests of the structure of these sequences in …