User profiles for Paul Simonson
Paul D SimonsonWeill Cornell Medicine Verified email at med.cornell.edu Cited by 543 |
Using fixed fiduciary markers for stage drift correction
To measure nanometric features with super-resolution requires that the stage, which holds
the sample, be stable to nanometric precision. Herein we introduce a new method that uses …
the sample, be stable to nanometric precision. Herein we introduce a new method that uses …
[HTML][HTML] Hospitalization and mortality associated with SARS-CoV-2 viral clades in COVID-19
The COVID-19 epidemic of 2019–20 is due to the novel coronavirus SARS-CoV-2. Following
first case description in December, 2019 this virus has infected over 10 million individuals …
first case description in December, 2019 this virus has infected over 10 million individuals …
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression
With a rising incidence of COVID-19–associated morbidity and mortality worldwide, it is
critical to elucidate the innate and adaptive immune responses that drive disease severity. We …
critical to elucidate the innate and adaptive immune responses that drive disease severity. We …
Single-molecule-based super-resolution images in the presence of multiple fluorophores
PD Simonson, E Rothenberg, PR Selvin - Nano letters, 2011 - ACS Publications
Several super-resolution techniques exist, yet most require multiple lasers, use either large
or weakly emitting fluorophores, or involve chemical manipulation. Here we show a simple …
or weakly emitting fluorophores, or involve chemical manipulation. Here we show a simple …
[HTML][HTML] Comparison of multiple clinical testing modalities for assessment of NPM1-mutant AML
…, J Racchumi, A Chadburn, P Simonson… - Frontiers in …, 2021 - frontiersin.org
Background NPM1 mutation status can influence prognosis and management in AML.
Accordingly, clinical testing (ie, RT-PCR, NGS and IHC) for mutant NPM1 is increasing in order to …
Accordingly, clinical testing (ie, RT-PCR, NGS and IHC) for mutant NPM1 is increasing in order to …
[PDF][PDF] Counting bungarotoxin binding sites of nicotinic acetylcholine receptors in mammalian cells with high signal/noise ratios
PD Simonson, HA DeBerg, P Ge, JK Alexander… - Biophysical journal, 2010 - cell.com
Nicotinic acetylcholine receptors are some of the most studied synaptic proteins; however,
many questions remain that can only be answered using single molecule approaches. Here …
many questions remain that can only be answered using single molecule approaches. Here …
[HTML][HTML] Tyramide-conjugated DNA barcodes enable signal amplification for multiparametric CODEX imaging
PD Simonson, I Valencia, SS Patel - Communications Biology, 2022 - nature.com
Multiparametric imaging allows researchers to measure the expression of many biomarkers
simultaneously, allowing detailed characterization of cell microenvironments. One such …
simultaneously, allowing detailed characterization of cell microenvironments. One such …
Two-photon 3D FIONA of individual quantum dots in an aqueous environment
R Zhang, E Rothenberg, G Fruhwirth, PD Simonson… - Nano …, 2011 - ACS Publications
We report the first two-photon (2P) microscopy of individual quantum dots (QDs) in an aqueous
environment with both widefield and point-scan excitations at nanometer accuracy. Thiol-…
environment with both widefield and point-scan excitations at nanometer accuracy. Thiol-…
[HTML][HTML] Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical …
With a rising incidence of COVID-19-associated morbidity and mortality worldwide, it is critical
to elucidate the innate and adaptive immune responses that drive disease severity. We …
to elucidate the innate and adaptive immune responses that drive disease severity. We …
Potential for process improvement of clinical flow cytometry by incorporating real-time automated screening of data to expedite addition of antibody panels: a single …
PD Simonson, AY Lee, D Wu - American Journal of Clinical …, 2022 - academic.oup.com
Objectives We desired an automated approach to expedite ordering additional antibody panels
in our clinical flow cytometry lab. This addition could improve turnaround times, decrease …
in our clinical flow cytometry lab. This addition could improve turnaround times, decrease …