The initiation of a primary immune response requires contact between dendritic cells (DCs)
and resting T cells. However, little is known about the proteins that mediate this initial contact. …

Expansion of human hematopoietic stem cells (HSCs) is a major challenge in cellular
therapy, and currently relies on the use of recombinant cytokines or on gene transfer of …

ERYTHROID-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1 ;
refs 1–3 respectively), the principal DNA-binding protein of the erythrocytic lineage. NF-E1 …

Porphobilinogen deaminase [PBGD; porphobilinogen ammonia-lyase (polymerizing), EC
4.3.1.8] is a cytosolic enzyme involved in the heme biosynthetic pathway. Two isoforms of …

Autonomic nerve fibres in the tumour microenvironment regulate cancer initiation and
dissemination, but how nerves emerge in tumours is currently unknown. Here we show that neural …

Tal-1 rearrangements are associated with nearly 30% of human T acute lymphoblastic leukemia.
Tal-1 gene encodes a putative transcription factor with a basic helix-loop-helix domain …

Understanding the pathways that regulate the human T-cell acute lymphoblastic leukemia (T-ALL)
initiating cells (T-LiC) activity has been hampered by the lack of biologic assays in …

We have studied the erythroid-specific promoter of the human gene coding for Porphobilinogen
Deaminase (PBGD) by DNaseI footprintng, gel retardation and methylation interference …

Two cis-acting sequences, recognized by two erythroid-specific trans-acting factors, are
involved in the regulation of the erythroid promoter of the human gene coding for …

The passage from proliferation to terminal differentiation is critical for normal development
and is often perturbed in malignancies. To define the molecular mechanisms that govern this …