Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …

During the processes leading to adverse cardiac remodeling and heart failure, cardiomyocytes
react to neurohumoral stimuli and biomechanical stress by activating pathways that …

MicroRNAs refer to a subfamily of small non-coding RNA species that are designed to
influence gene expression in nearly all cell types studied to date. Studies from the past decade …

MicroRNAs (miRs) are a class of single-stranded, non-coding RNAs of about 22 nucleotides
in length 1 , 2 . Increasing evidence implicates miRs in myocardial disease processes 3 , 4 , …

Background— Dicer, an RNAse III endonuclease critical for processing of pre-microRNAs (miRNAs)
into mature 22-nucleotide miRNAs, has proven a useful target to dissect the …

Objectives : The purpose of this paper was to determine whether microRNAs (miRNAs)
involved in myocardial remodeling were differentially expressed in the blood of hypertrophic …

Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels.
However, the role of VSMC autophagy in cardiovascular disease is poorly understood. …

Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy
metabolism in the heart. Here, we propose a mechanism that integrates two deleterious …

One major intracellular signaling pathway involved in heart failure employs the phosphatase
calcineurin and its downstream transcriptional effector nuclear factor of activated T-cells (…

Although aberrant reactivation of embryonic gene programs is intricately linked to
pathological heart disease, the transcription factors driving these gene programs remain ill-defined. …