Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

Capture Hi-C (CHi-C) is a method for profiling chromosomal interactions involving targeted
regions of interest, such as gene promoters, globally and at high resolution. Signal detection …

The human brain has undergone rapid expansion since humans diverged from other great
apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use …

Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with trailing
ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate protein …

10.7554/eLife.21926.001 Long-range cis-regulatory elements such as enhancers coordinate
cell-specific transcriptional programmes by engaging in DNA looping interactions with …

Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with
promoters to regulate cell-type-specific gene expression. SEs are characterized by high …

In order to explore and interact with their surroundings, animals need to orient toward specific
positions in space. Throughout the animal kingdom, head movements represent a primary …

Long-range chromosomal interactions bring distal regulatory elements and promoters together
to regulate gene expression in biological processes. By performing promoter capture Hi-…

Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions
involving, at least on one end, regions of interest such as gene promoters. Signal detection in …

Objective: Vascular inflammation underlies cardiovascular disease. Vascular smooth muscle
cells (VSMCs) upregulate selective genes, including MMPs (matrix metalloproteinases) …