The NLRP3–inflammasome as a sensor of organelle dysfunction
Diverse pathogen- and damage-associated stresses drive inflammation via activation of the
multimolecular NLRP3–inflammasome complex. How the effects of diverse stimuli are …
multimolecular NLRP3–inflammasome complex. How the effects of diverse stimuli are …
Vomocytosis: what we know so far
PI Seoane, RC May - Cellular microbiology, 2020 - Wiley Online Library
Vomocytosis, or nonlytic exocytosis, has been reported for Cryptococcus neoformans since
2006. Since then, the repertoire of vomocytosing pathogens and host cells has increased …
2006. Since then, the repertoire of vomocytosing pathogens and host cells has increased …
[HTML][HTML] The laminated layer: Recent advances and insights into Echinococcus biology and evolution
Á Díaz, C Fernández, Á Pittini, PI Seoane… - Experimental …, 2015 - Elsevier
The laminated layer is the unique mucin-based extracellular matrix that protects Echinococcus
larvae, and thus to an important extent, shapes host–parasite relationships in the larval …
larvae, and thus to an important extent, shapes host–parasite relationships in the larval …
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
…, DM Williams, BJ Matchett, PI Seoane… - Science …, 2023 - science.org
Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling
pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that …
pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that …
[HTML][HTML] Characterizing the mechanisms of nonopsonic uptake of cryptococci by macrophages
The pathogenic fungus Cryptococcus enters the human host via inhalation into the lung and
is able to reside in a niche environment that is serum-(opsonin) limiting. Little is known …
is able to reside in a niche environment that is serum-(opsonin) limiting. Little is known …
Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5
AS Gilbert, PI Seoane, P Sephton-Clark… - Science …, 2017 - science.org
Vomocytosis, or nonlytic extrusion, is a poorly understood process through which macrophages
release live pathogens that they have failed to kill back into the extracellular environment…
release live pathogens that they have failed to kill back into the extracellular environment…
Unconventional maturation of dendritic cells induced by particles from the laminated layer of larval Echinococcus granulosus
C Casaravilla, Á Pittini, D Rückerl, PI Seoane… - Infection and …, 2014 - Am Soc Microbiol
The larval stage of the cestode parasite Echinococcus granulosus causes hydatid disease
in humans and livestock. This infection is characterized by the growth in internal organ …
in humans and livestock. This infection is characterized by the growth in internal organ …
[HTML][HTML] Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages
Cryptococcus neoformans is an opportunistic human pathogen, which causes serious disease
in immunocompromised hosts. Infection with this pathogen is particularly relevant in HIV + …
in immunocompromised hosts. Infection with this pathogen is particularly relevant in HIV + …
Subcritical water for the extraction and hydrolysis of protein and other fractions in biorefineries from agro-food wastes and algae: A review
M Álvarez-Viñas, P Rodríguez-Seoane… - Food and Bioprocess …, 2021 - Springer
Low-cost plant and algal biomass are increasingly demanded as a source of proteins, and
also, peptides and amino acids are gaining interest for their biological and functional …
also, peptides and amino acids are gaining interest for their biological and functional …
Microwave-assisted water extraction
PR Seoane, N Flórez-Fernández, EC Piñeiro… - Water Extraction of …, 2017 - Elsevier
Microwave-assisted aqueous extraction processes and solvent-free microwave-assisted
extraction, using the water naturally present in vegetal materials, are promising for the …
extraction, using the water naturally present in vegetal materials, are promising for the …