Major depressive disorder (MDD) is a prevalent and disabling psychiatric disease with rates
of non-responsiveness to antidepressants ranging from 30–50%. Historically, the …

Cerebral perfusion dysfunctions are seen in the early stages of Alzheimer's disease (AD). We
systematically reviewed the literature to investigate the effect of pharmacological and non-…

Evidence suggests that exercise can modulate neuroinflammation and neuronal damage.
We evaluated if such effects of exercise can be detected with positron emission tomography (…

… Paula Kopschina Feltes, Erik FJ de Vries and Janine Doorduin designed the study and
experiments. Paula Kopschina Feltes acquired the … Paula Kopschina Feltes analysed the data. …

The increasing incidence of cancer over the years is one of the most challenging problems
in healthcare. As cancer progresses, the recruitment of several immune cells is triggered. …

[ 11 C]UCB-J is a novel radioligand that binds to synaptic vesicle glycoprotein 2A (SV2A).
The main objective of this study was to determine the 28-day test–retest repeatability (TRT) of …

11 C-PBR28 is a second-generation translocator protein (TSPO) tracer with characteristics
supposedly superior to the most commonly used tracer for neuroinflammation, (R)- 11 C-…

Objective Temporal lobe epilepsy ( TLE ) is one of the most common types of epilepsy
syndromes in the world. Depression is an important comorbidity of epilepsy, which has been …

Background: Individuals at 80 years of age or above with exceptional memory are considered
SuperAgers (SA), an operationalized definition of successful cognitive aging. SA showed …

[ 11 C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A.
Therefore, [ 11 C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main …