Background Numerous microRNAs (miRNAs) have heterogeneous ends resulting from
imprecise cleavages by processing nucleases and from various non-templated nucleotide …

The ribonuclease Dicer excises mature miRNAs from a diverse group of precursors (pre-miRNAs),
most of which contain various secondary structure motifs in their hairpin stem. In this …

Numerous types of transcripts perform multiple functions in cells, and these functions are
mainly facilitated by the interactions of the RNA with various proteins and other RNAs. Insight …

Background miRNAs are considered important players in oncogenesis, serving either as
oncomiRs or suppressormiRs. Although the accumulation of somatic alterations is an intrinsic …

It is a well-known and intensively studied phenomenon that the levels of many miRNAs are
differentiated in cancer. miRNA biogenesis and functional expression are complex processes …

The deep-sequencing of small RNAs has revealed that different numbers and proportions of
miRNA variants called isomiRs are formed from single miRNA genes and that this effect is …

A growing body of evidence indicates that miRNAs may either drive or suppress oncogenesis.
However, little is known about somatic mutations in miRNA genes. To determine the …

Tandem repeats of various trinucleotide motifs are frequent entities in transcripts, and RNA
structures formed by these sequences depend on the motif type and number of reiterations. …

Repeat-associated disorders caused by expansions of short sequences have been classified
as coding and noncoding and are thought to be caused by protein gain-of-function and …

Recent data indicate that MIR142 is the most frequently mutated miRNA gene and one of
the most frequently mutated noncoding elements in all cancers, with mutations occurring …