The frequent loss of chromosome 17 in epithelial ovarian carcinomas (EOC), particularly
high-grade serous carcinomas (HGSC), has been attributed to the disruption of TP53 (at 17p13. …

High-grade ovarian serous carcinomas (HGSC) are characterized by TP53 mutations and
non-random patterns of chromosomal anomalies, where the nature of the TP53 mutation may …

Previous studies have implicated vestigial like 3 (VGLL3), a chromosome 3p12.3 gene that
encodes a putative transcription co-factor, as a candidate tumor suppressor gene (TSG) in …

Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing
them from forming active transcription complexes that drive changes in cell states. Id …

ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in
cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and …

It has been proposed that the frequent loss of heterozygosity (LOH) of an entire chromosome
17 contig in epithelial ovarian cancers (EOC) is the consequence of the inactivation of …

Polymeric nanocarriers such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers
deliver drugs to solid tumors and avoid the systemic toxicity of conventional chemotherapy. …

Background As gene expression signatures may serve as biomarkers, there is a need to
develop technologies based on mRNA expression patterns that are adaptable for translational …

Id proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in
cancer. Id proteins inhibit basic HLH transcription factors through protein-protein interactions…

The integrated stress response (ISR) is an adaptive signaling pathway that cells utilize to
respond to a wide range of extrinsic and intrinsic stresses, many of which are important for …