User profiles for Pauline Lempens
 | Pauline LempensTuberculosis Consultant at KNCV Tuberculosis Foundation Verified email at kncvtbc.org Cited by 361 |
[HTML][HTML] The relationship between transmission time and clustering methods in Mycobacterium tuberculosis epidemiology
…, C Utpatel, P Beckert, F Gehre, P Lempens… - …, 2018 - thelancet.com
Background Tracking recent transmission is a vital part of controlling widespread pathogens
such as Mycobacterium tuberculosis. Multiple methods with specific performance …
such as Mycobacterium tuberculosis. Multiple methods with specific performance …
[HTML][HTML] Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations
The majority of Mycobacterium tuberculosis isolates resistant to isoniazid harbour a mutation
in katG. Since these mutations cause a wide range of minimum inhibitory concentrations (…
in katG. Since these mutations cause a wide range of minimum inhibitory concentrations (…
[HTML][HTML] Management of multidrug-resistant tuberculosis with shorter treatment regimen in Niger: nationwide programmatic achievements
Background In Niger, the Shorter Treatment Regimen (STR) has been implemented nationwide
for rifampicin resistant tuberculosis (RR-TB), since 2008. No previous publication has …
for rifampicin resistant tuberculosis (RR-TB), since 2008. No previous publication has …
[HTML][HTML] Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen
P Lempens, T Decroo, KJM Aung, MA Hossain… - International Journal of …, 2020 - Elsevier
Objectives We investigated whether companion drug resistance was associated with adverse
outcomes of the shorter multidrug-resistant tuberculosis (MDR-TB) treatment regimen in …
outcomes of the shorter multidrug-resistant tuberculosis (MDR-TB) treatment regimen in …
Multidrug-resistant patients receiving treatment in Niger who are infected with M. tuberculosis Cameroon family convert faster in smear and culture than those with M …
…, S Hassane-Harouna, MB Souleymane, P Lempens… - Tuberculosis, 2020 - Elsevier
In this study, we analyzed the M. tuberculosis complex (MTBc) population structure among
multidrug-resistant TB (MDR-TB) patients in Niger and tested whether the Cameroon family …
multidrug-resistant TB (MDR-TB) patients in Niger and tested whether the Cameroon family …
[HTML][HTML] Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century
…, G Torrea, T Decroo, E Kamanzi, P Lempens… - Journal of Clinical …, 2022 - Elsevier
background Multidrug-resistant (MDR) tuberculosis (TB) poses an important challenge in
TB management and control. Rifampicin resistance (RR) is a solid surrogate marker of MDR-TB…
TB management and control. Rifampicin resistance (RR) is a solid surrogate marker of MDR-TB…
Borderline rpoB mutations transmit at the same rate as common rpoB mutations in a tuberculosis cohort in Bangladesh
P Lempens, A Van Deun, KJM Aung… - Microbial …, 2023 - microbiologyresearch.org
The spread of multidrug-resistant tuberculosis (MDR-TB) is a growing problem in many
countries worldwide. Resistance to one of the primary first-line drugs, rifampicin, is caused by …
countries worldwide. Resistance to one of the primary first-line drugs, rifampicin, is caused by …
[HTML][HTML] Bridging the TB data gap: in silico extraction of rifampicin-resistant tuberculosis diagnostic test results from whole genome sequence data
Background Mycobacterium tuberculosis rapid diagnostic tests (RDTs) are widely employed
in routine laboratories and national surveys for detection of rifampicin-resistant (RR)-TB. …
in routine laboratories and national surveys for detection of rifampicin-resistant (RR)-TB. …
Rifampicin-Resistant Tuberculosis Control in Rwanda Overcomes a Successful Clone That Causes Most Disease Over a Quarter Century
…, G Torrea, T Decroo, E Kamanzi, P Lempens… - papers.ssrn.com
Background: Rifampicin-resistance (RR) poses an important challenge in tuberculosis (TB)
management and control. Understanding the driving factors behind the rising numbers of RR-…
management and control. Understanding the driving factors behind the rising numbers of RR-…
Initial resistance to companion drugs should not be considered an exclusion criterion for the multidrug-resistant tuberculosis shorter treatment regimen
P Lempens, T Decroo, KJM Aung, MA Hossain… - 2020 - bradscholars.brad.ac.uk
We investigated whether companion drug resistance was associated with adverse outcome
of the shorter MDR-TB regimen in Bangladesh, after adjusting for fluoroquinolone resistance…
of the shorter MDR-TB regimen in Bangladesh, after adjusting for fluoroquinolone resistance…