Introduction of clonal reproduction through seeds (apomixis) in crops has the potential to
revolutionize agriculture by allowing self-propagation of any elite variety, in particular F1 hybrids…

Engineered bacteria promise to revolutionize diagnostics and therapeutics, yet many applications
are precluded by the limited number of detectable signals. Here we present a general …

A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges
in manufacturing, environmental remediation, and healthcare. Recombinase devices can …

Genetic programs operating in a history-dependent fashion are ubiquitous in nature and
govern sophisticated processes such as development and differentiation. The ability to …

Chemically-induced dimerization (CID) systems are essential tools to interrogate and control
biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine …

Engineered bacteria are promising candidates for in situ detection and treatment of diseases.
The female uro-genital tract presents several pathologies, such as sexually transmitted …

Bacteria equipped with genetically encoded lactate biosensors are promising tools for
biopharmaceutical production, diagnostics, and cellular therapies. However, many applications …

Cdc25 dual-specificity phosphatases coordinate entry into mitosis through activating
dephosphorylation of the Mitosis-Promoting Factor, Cdk1-cyclin B1. Activation of Cdc25C at the G2/…

Gut metabolites are pivotal mediators of host-microbiome interactions and provide an
important window on human physiology and disease. However, current methods to monitor gut …

Ubiquitin serves as a molecular zipcode to direct and sort ubiquitinylated proteins into distinct
biological pathways. Although novel modes of ubiquitin interaction have recently been …