Background Bone and joint infection, mainly caused by Staphylococcus aureus, is
associated with significant morbidity and mortality, characterized by severe inflammation and …

Dystrophic epidermolysis bullosa (DEB) is a blistering skin disease caused by mutations in
the gene COL7A1 encoding collagen VII. DEB can be inherited as recessive DEB (RDEB) or …

As the outermost layer of the skin, the epidermis is playing a major role in organism
homeostasis providing the first barrier against external aggressions. Although considered as an …

Extracellular matrix (ECM) proteins are major components of most tissues and organs. In
addition to their crucial role in tissue cohesion and biomechanics, they chiefly regulate various …

Collagens are the most abundant vertebrate extracellular matrix proteins. They form a
superfamily of 28 members that show a remarkable diversity in molecular and supramolecular …

Recessive dystrophic epidermolysis bullosa (RDEB), a genetic skin blistering disease, is a
paradigmatic condition of tissue fragility‐driven multi‐organ fibrosis. Here, longitudinal …

The myotendinous junction (MTJ) is essential for the integrity of the musculoskeletal unit.
Here, we show that gene ablation of the MTJ marker col22a1 in zebrafish results in MTJ …

How some animals regenerate missing body parts is not well understood. Taking
advantage of the zebrafish caudal fin model, we performed a global unbiased time-course …

Collagens are the most abundant extracellular matrix proteins in multicellular organisms. In
humans, the collagen superfamily counts 28 proteins encoded by 44 genes whose functions …

Background Netherton syndrome (NS) is a rare but severe type of ichthyosis characterized
by atopy, allergies, and potentially lethal skin overdesquamation associated with highly …