OBJECTIVES: The increasing incidence of nonalcoholic (NASH) and alcoholic steatohepatitis
(ASH), associated with lack of effective treatment, has prompted intensive studies on …

Tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, modulates cell death by
interrupting classic pathways of apoptosis. Intracerebral hemorrhage (ICH) is a devastating …

Metazoans tolerate commensal-gut microbiota by suppressing immune activation while
maintaining the ability to launch rapid and balanced immune reactions to pathogenic bacteria. …

The Hippo (Hpo) pathway is a central determinant of tissue size in both Drosophila and higher
organisms. The core of the pathway is a kinase cascade composed of an upstream kinase …

The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains
poorly understood. Here, we show that the Spectrin cytoskeleton controls Hippo signalling. In …

Caspases have been extensively studied as critical initiators and executioners of cell death
pathways. However, caspases also take part in non‐apoptotic signalling events such as the …

How tissues acquire their characteristic shape is a fundamental unresolved question in
biology. While genes have been characterized that control local mechanical forces to elongate …

Cellular signalling lies at the heart of every decision involved in the development and
homeostasis of multicellular organisms. The Hippo pathway was discovered nearly two decades …

… RM Ramalho and PS Ribeiro contributed equally to this work… RM Ramalho and PS Ribeiro
contributed equally to this work. … RM Ramalho and PS Ribeiro contributed equally to this work. …

As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO)
proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/…