The effect of alterations in intestinal microbiota on microbial metabolites and on disease
processes such as graft-versus-host disease (GVHD) is not known. Here we carried out an …

Alloantigen expression on host antigen-presenting cells (APCs) is essential to initiate graft-versus-host
disease (GvHD); therefore, alloantigen expression on host target epithelium is …

Purpose Thirty percent to 90% of cancer survivors report impaired sleep quality post-treatment,
which can be severe enough to increase morbidity and mortality. Lifestyle interventions, …

Haemopoietic-cell transplantation (HCT) is an intensive therapy used to treat high-risk
haematological malignant disorders and other life-threatening haematological and genetic …

Background The recurrence score based on the 21-gene breast cancer assay predicts
chemotherapy benefit if it is high and a low risk of recurrence in the absence of chemotherapy if it …

Background Prior studies with the use of a prospective–retrospective design including
archival tumor samples have shown that gene-expression assays provide clinically useful …

PURPOSE CheckMate 568 is an open-label phase II trial that evaluated the efficacy and safety
of nivolumab plus low-dose ipilimumab as first-line treatment of advanced/metastatic non…

Complications of allogeneic hematopoietic stem cell transplantation (HSCT) remain barriers
to its wider application for a variety of diseases. Graft-versus-host disease (GVHD) is the …

Background The use of adjuvant chemotherapy in patients with breast cancer may be guided
by clinicopathological factors and a score based on a 21-gene assay to determine the risk …

No validated biomarkers exist for acute graft-versus-host disease (GVHD). We screened
plasma with antibody microarrays for 120 proteins in a discovery set of 42 patients who …