User profiles for Pavel Kielkowski

Pavel Kielkowski

LMU München
Verified email at tum.de
Cited by 589

5-Substituted pyrimidine and 7-substituted 7-deazapurine dNTPs as substrates for DNA polymerases in competitive primer extension in the presence of natural dNTPs

H Cahová, A Panattoni, P Kielkowski… - ACS Chemical …, 2016 - ACS Publications
A complete series of 5-substituted uracil or cytosine, as well as 7-substituted 7-deazaadenine
and 7-deazaguanine 2′-deoxyribonucleoside triphosphates (dNTPs) bearing …

7‐Aryl‐7‐deazaadenine 2′‐deoxyribonucleoside triphosphates (dNTPs): better substrates for DNA polymerases than dATP in competitive incorporations

P Kielkowski, J Fanfrlík, M Hocek - … Chemie International Edition, 2014 - Wiley Online Library
A series of 7‐substituted 7‐deazaadenine and 5‐substituted cytosine 2′‐deoxyribonucleoside
triphosphates (dNTPs) were tested for their competitive incorporations (in the presence …

[HTML][HTML] Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity

…, AC O'neill, A Brazovskaja, Z He, P Kielkowski… - Nature …, 2021 - nature.com
Basal progenitors (BPs), including intermediate progenitors and basal radial glia, are
generated from apical radial glia and are enriched in gyrencephalic species like humans, …

[HTML][HTML] FICD activity and AMPylation remodelling modulate human neurogenesis

P Kielkowski, IY Buchsbaum, VC Kirsch… - Nature …, 2020 - nature.com
Posttranslational modification (PTM) of proteins represents an important cellular mechanism
for controlling diverse functions such as signalling, localisation or protein–protein …

ECE 2 regulates neurogenesis and neuronal migration during human cortical development

IY Buchsbaum, P Kielkowski, G Giorgio, AC O'Neill… - EMBO …, 2020 - embopress.org
During embryonic development, excitatory projection neurons migrate in the cerebral cortex
giving rise to organised layers. Periventricular heterotopia ( PH ) is a group of aetiologically …

Selective activation of human caseinolytic protease P (ClpP)

…, M Gersch, A Pahl, P Kielkowski… - Angewandte Chemie …, 2018 - Wiley Online Library
Caseinolytic protease P (ClpP) is the proteolytic component of the ClpXP protein
degradation complex. Eukaryotic ClpP was recently found to act within the mitochondria‐specific …

Transient and switchable (triethylsilyl) ethynyl protection of DNA against cleavage by restriction endonucleases

P Kielkowski, H Macíčková‐Cahová, R Pohl… - Angewandte Chemie, 2011 - infona.pl
Eingeschränkter Zugang zu DNA: (Triethylsilyl)ethinyl‐modifiziertes 7‐desaza‐dATP kann
durch Primer‐Verlängerung oder Polymerase‐Kettenreaktion mit KOD XL‐Polymerase in …

A pronucleotide probe for live‐cell imaging of protein AMPylation

P Kielkowski, IY Buchsbaum, T Becker, K Bach… - …, 2020 - Wiley Online Library
Conjugation of proteins to AMP (AMPylation) is a prevalent post‐translational modification (PTM)
in human cells, involved in the regulation of unfolded protein response and neural …

[PDF][PDF] From young to old: AMPylation hits the brain

SA Sieber, S Cappello, P Kielkowski - Cell Chemical Biology, 2020 - cell.com
Protein post-translational modifications (PTMs) are implicated in numerous physiological
processes and significantly contribute to complex regulatory networks of protein functions. …

Synthesis of acetylene linked double-nucleobase nucleos (t) ide building blocks and polymerase construction of DNA containing cytosines in the major groove

P Kielkowski, R Pohl, M Hocek - The Journal of organic chemistry, 2011 - ACS Publications
(Cytosin-5-yl)ethynyl derivatives of pyrimidine and 7-deazaadenine 2-deoxyribonucleosides
and nucleoside triphosphates (dNTPs) were prepared in one step by the aqueous …