OBJECTIVE: To evaluate the safety and efficacy of pregabalin in the management of
chemotherapy-induced neuropathic pain in patients with childhood solid tumors and leukaemia. …

Background: The outcome of children with refractory/relapsed malignancies remains poor
and novel therapies are urgently required. One of the promising approaches is metronomic …

To outline an outpatient-based treatment for children with relapsed solid tumors, who
already have been extensively pretreated, we defined a 4-drug protocol named COMBAT (…

The authors describe the case of a 5-year-old girl with recurrent laryngeal papillomatosis (RLP)
due to human papillomavirus (HPV) type 11, who required frequent surgical treatment. …

For decades, retinoids and their synthetic derivatives have been well established anticancer
treatments due to their ability to regulate cell growth and induce cell differentiation and …

Retinoids represent a popular group of differentiation inducers that are successfully used in
oncology for treatment of acute promyelocytic leukemia in adults and of neuroblastoma in …

In this study, the circulating miRNome from diagnostic neuroblastoma serum was assessed
for identification of noninvasive biomarkers with potential in monitoring metastatic disease. …

The metronomic therapy concept uses low doses of continuously applied chemotherapeutic,
anti-angiogenetic, and immunomodulating drugs. Twenty patients with recurrent and 3 with …

Background Neuroblastoma is a frequently lethal pediatric cancer in which MYCN genomic
amplification is highly correlated with aggressive disease. Deregulated MYC genes require …

Research has exposed cancer to be a heterogeneous disease with a high degree of inter-tumoral
and intra-tumoral variability. Individual tumors have unique profiles, and these …