The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

During the COVID-19 pandemic, genomics and bioinformatics have emerged as essential
public health tools. The genomic data acquired using these methods have supported the …

We report principles and guidelines (Supplementary Note) that were developed by the Next-Generation
Sequencing: Standardization of Clinical Testing II (Nex-StoCT II) informatics …

Aligning sequencing reads onto a reference is an essential step of the majority of genomic
analysis pipelines. Computational algorithms for read alignment have evolved in accordance …

Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks
of hepatitis C virus (HCV) infections are associated with unsafe injection practices, drug …

Motivation Genomic analysis has become one of the major tools for disease outbreak
investigations. However, existing computational frameworks for inference of transmission history …

The unprecedented coverage offered by next-generation sequencing (NGS) technology has
facilitated the assessment of the population complexity of intra-host RNA viral populations at …

Background Next-generation sequencing allows the analysis of an unprecedented number
of viral sequence variants from infected patients, presenting a novel opportunity for …

… Pavel Skums … Pavel Skums … Chandran, Pavel Skums, Michael R. Shurin, Alex
Zelikovsky, Walter J. Storkus, Yuri L. …

Public health intervention to contain the ongoing COVID-19 pandemic significantly differed
by country since the SARS-CoV-2 spread varied regionally in time and in scale. Since …