Transfer across the blood‐brain barrier (BBB) remains a significant hurdle for the development
of biopharmaceuticals with therapeutic effects within the central nervous system. We …

Ras mutations are the oncogenic drivers of many human cancers and yet there are still no
approved Ras-targeted cancer therapies. Inhibition of Ras nucleotide exchange is a …

Heat shock protein 70 (Hsp70) has gained a lot of attention in the past decade due to its
potential immunoregulatory functions. Some of the described proinflammatory functions of …

Transferrin receptor 1 (TfR1) mediated transcytosis is an attractive strategy to enhance brain
uptake of protein drugs, but translation remains a challenge. Here, a single domain shark …

Exposure to temperatures over a certain limit leads to massive protein aggregation in the
cell. Disaggregation of such aggregates is largely dependent on the Hsp100 and Hsp70 …

Single domain shark variable domain of new antigen receptor (VNAR) antibodies can offer
a viable alternative to conventional Ig‐based monoclonal antibodies in treating COVID‐19 …

Background The higher prevalence of Asperger Syndrome (AS) and other autism spectrum
conditions in males has been known for many years. However, recent multiplex …

Single domain shark antibodies that bind to the transferrin receptor 1 (TfR1) on brain
endothelial cells have been used to shuttle antibodies and other cargos across the blood brain …

Heat shock protein 70 (HSP70) has previously been described as a potent antitumour vaccine.
The mechanism relied on the ability of tumour derived HSP70 to associate with antigenic …

Protein folding within the endoplasmic reticulum is assisted by molecular chaperones and
folding catalysts that include members of the protein-disulfide isomerase and peptidyl-prolyl …