User profiles for Payel Sil
Payel SilNational Institutes of Health (NIH) Verified email at nih.gov Cited by 13691 |
Rubicon: LC 3‐associated phagocytosis and beyond
Rubicon (Rubcn) was initially identified as a component of the Class III PI 3K complex and a
negative regulator of canonical autophagy and endosomal trafficking. However, Rubicon …
negative regulator of canonical autophagy and endosomal trafficking. However, Rubicon …
A ravenous defense: canonical and non-canonical autophagy in immunity
P Sil, G Muse, J Martinez - Current opinion in immunology, 2018 - Elsevier
Highlights • Pathogens can be targeted by autophagic machinery in a process termed selective
autophagy. • In xenophagy, pathogens are ubiquitinated and delivered to LC3+ vacuoles …
autophagy. • In xenophagy, pathogens are ubiquitinated and delivered to LC3+ vacuoles …
[HTML][HTML] More than skin deep: autophagy is vital for skin barrier function
The skin is a highly organized first line of defense that stretches up to 1.8 m 2 and is home to
more than a million commensal bacteria. The microenvironment of skin is driven by factors …
more than a million commensal bacteria. The microenvironment of skin is driven by factors …
Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation
Objective and design Arthritic gout is caused by joint inflammation triggered by the
damaging effects of monosodium uric acid (MSU) crystal accumulation in the synovial space. …
damaging effects of monosodium uric acid (MSU) crystal accumulation in the synovial space. …
[HTML][HTML] Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa
M Floyd, M Winn, C Cullen, P Sil, B Chassaing… - PLoS …, 2016 - journals.plos.org
Pseudomonas aeruginosa is an opportunistic pathogen causing severe infections often
characterized by robust neutrophilic infiltration. Neutrophils provide the first line of defense …
characterized by robust neutrophilic infiltration. Neutrophils provide the first line of defense …
P2Y6 receptor antagonist MRS2578 inhibits neutrophil activation and aggregated neutrophil extracellular trap formation induced by gout-associated monosodium …
P Sil, CP Hayes, BJ Reaves, P Breen… - The Journal of …, 2017 - journals.aai.org
Human neutrophils (polymorphonuclear leukocytes [PMNs]) generate inflammatory responses
within the joints of gout patients upon encountering monosodium urate (MSU) crystals. …
within the joints of gout patients upon encountering monosodium urate (MSU) crystals. …
High throughput measurement of extracellular DNA release and quantitative NET formation in human neutrophils in vitro
Neutrophil granulocytes are the most abundant leukocytes in the human blood. Neutrophils
are the first to arrive at the site of infection. Neutrophils developed several antimicrobial …
are the first to arrive at the site of infection. Neutrophils developed several antimicrobial …
NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases
Objective and design We studied the involvement of calcium and calcium-activated NADPH
oxidases in NLRP3 inflammasome activation and IL-1β release to better understand …
oxidases in NLRP3 inflammasome activation and IL-1β release to better understand …
[HTML][HTML] DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating
autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads to …
autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads to …
[HTML][HTML] Non-canonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure
BACKGROUND: Control of the inflammatory response is critical to maintaining homeostasis,
and failure to do so contributes to the burden of chronic inflammation associated with …
and failure to do so contributes to the burden of chronic inflammation associated with …