User profiles for Payel Sil

Payel Sil

National Institutes of Health (NIH)
Verified email at nih.gov
Cited by 13691

Rubicon: LC 3‐associated phagocytosis and beyond

SW Wong, P Sil, J Martinez - The FEBS journal, 2018 - Wiley Online Library
Rubicon (Rubcn) was initially identified as a component of the Class III PI 3K complex and a
negative regulator of canonical autophagy and endosomal trafficking. However, Rubicon …

A ravenous defense: canonical and non-canonical autophagy in immunity

P Sil, G Muse, J Martinez - Current opinion in immunology, 2018 - Elsevier
Highlights • Pathogens can be targeted by autophagic machinery in a process termed selective
autophagy. • In xenophagy, pathogens are ubiquitinated and delivered to LC3+ vacuoles …

[HTML][HTML] More than skin deep: autophagy is vital for skin barrier function

P Sil, SW Wong, J Martinez - Frontiers in Immunology, 2018 - frontiersin.org
The skin is a highly organized first line of defense that stretches up to 1.8 m 2 and is home to
more than a million commensal bacteria. The microenvironment of skin is driven by factors …

Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation

P Sil, H Wicklum, C Surell, B Rada - Inflammation Research, 2017 - Springer
Objective and design Arthritic gout is caused by joint inflammation triggered by the
damaging effects of monosodium uric acid (MSU) crystal accumulation in the synovial space. …

[HTML][HTML] Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa

M Floyd, M Winn, C Cullen, P Sil, B Chassaing… - PLoS …, 2016 - journals.plos.org
Pseudomonas aeruginosa is an opportunistic pathogen causing severe infections often
characterized by robust neutrophilic infiltration. Neutrophils provide the first line of defense …

P2Y6 receptor antagonist MRS2578 inhibits neutrophil activation and aggregated neutrophil extracellular trap formation induced by gout-associated monosodium …

P Sil, CP Hayes, BJ Reaves, P Breen… - The Journal of …, 2017 - journals.aai.org
Human neutrophils (polymorphonuclear leukocytes [PMNs]) generate inflammatory responses
within the joints of gout patients upon encountering monosodium urate (MSU) crystals. …

High throughput measurement of extracellular DNA release and quantitative NET formation in human neutrophils in vitro

P Sil, D Yoo, M Floyd, A Gingerich, B Rada - JoVE (Journal of Visualized …, 2016 - jove.com
Neutrophil granulocytes are the most abundant leukocytes in the human blood. Neutrophils
are the first to arrive at the site of infection. Neutrophils developed several antimicrobial …

NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases

B Rada, JJ Park, P Sil, M Geiszt, TL Leto - Inflammation Research, 2014 - Springer
Objective and design We studied the involvement of calcium and calcium-activated NADPH
oxidases in NLRP3 inflammasome activation and IL-1β release to better understand …

[HTML][HTML] DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer

W Li, H Nakano, W Fan, Y Li, P Sil, K Nakano, F Zhao… - JCI insight, 2023 - ncbi.nlm.nih.gov
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating
autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads to …

[HTML][HTML] Non-canonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure

P Sil, J Suwanpradid, G Muse, A Gruzdev… - The Journal of allergy …, 2020 - ncbi.nlm.nih.gov
BACKGROUND: Control of the inflammatory response is critical to maintaining homeostasis,
and failure to do so contributes to the burden of chronic inflammation associated with …