Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter 1 , 2 that activates
the largest subtype family of G-protein-coupled receptors 3 . Drugs that target 5-HT 1A , 5-…

The D1- and D2-dopamine receptors (D1R and D2R), which signal through G s and G i ,
respectively, represent the principal stimulatory and inhibitory dopamine receptors in the central …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has
become the dominant infective strain. We report the structures of the Omicron spike trimer on …

Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12
different G protein-coupled receptors (GPCRs) through selective coupling of G s , G i, or G q …

Luteinizing hormone and chorionic gonadotropin are glycoprotein hormones that are related
to follicle-stimulating hormone and thyroid-stimulating hormone 1 , 2 . Luteinizing hormone …

RNA-guided systems, which use complementarity between a guide RNA and target nucleic
acid sequences for recognition of genetic elements, have a central role in biological …

Thyroid-stimulating hormone (TSH), through activation of its G-protein-coupled thyrotropin
receptor (TSHR), controls the synthesis of thyroid hormone—an essential metabolic hormone …

Ghrelin, also called “the hunger hormone”, is a gastric peptide hormone that regulates food
intake, body weight, as well as taste sensation, reward, cognition, learning and memory. One …

Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP),
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several multi-…

Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte
migration and inflammatory responses. Here, we present cryo-electron microscopy …