Role of prolyl hydroxylation in the molecular interactions of collagens
P Rappu, AM Salo, J Myllyharju… - Essays in biochemistry, 2019 - portlandpress.com
Co- and post-translational hydroxylation of proline residues is critical for the stability of the
triple helical collagen structure. In this review, we summarise the biology of collagen prolyl 4-…
triple helical collagen structure. In this review, we summarise the biology of collagen prolyl 4-…
Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction
…, L Lippens, MA De Scheerder, I Miinalainen, P Rappu… - Gut, 2020 - gut.bmj.com
We read with interest recent papers reporting on the impact of gut microbiota on several
aspects of health and disease due to altered intestinal permeability resulting in systemic …
aspects of health and disease due to altered intestinal permeability resulting in systemic …
Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine
…, L Lippens, I Miinalainen, P Rappu… - Journal of …, 2020 - Taylor & Francis
Extracellular vesicles (EV) are increasingly being recognized as important vehicles of
intercellular communication and promising diagnostic and prognostic biomarkers in cancer. …
intercellular communication and promising diagnostic and prognostic biomarkers in cancer. …
Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-) analytical variables
E Geeurickx, L Lippens, P Rappu, BG De Geest… - Nature protocols, 2021 - nature.com
The diagnostic and therapeutic use of extracellular vesicles (EV) is under intense investigation
and may lead to societal benefits. Reference materials are an invaluable resource for …
and may lead to societal benefits. Reference materials are an invaluable resource for …
Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics
…, A Decock, I Miinalainen, P Rappu… - Journal of …, 2023 - Wiley Online Library
The analysis of extracellular vesicles (EV) in blood samples is under intense investigation
and holds the potential to deliver clinically meaningful biomarkers for health and disease. …
and holds the potential to deliver clinically meaningful biomarkers for health and disease. …
FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
…, EA Cordasco, J Li, XL Chen, G Fu, M Ojalill, P Rappu… - Elife, 2019 - elifesciences.org
10.7554/eLife.47327.001 Gene copy number alterations, tumor cell stemness, and the
development of platinum chemotherapy resistance contribute to high-grade serous ovarian …
development of platinum chemotherapy resistance contribute to high-grade serous ovarian …
[HTML][HTML] Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms
KH Sipilä, K Drushinin, P Rappu, J Jokinen… - Journal of Biological …, 2018 - ASBMB
Collagens are the most abundant extracellular matrix proteins in vertebrates and have a
characteristic triple-helix structure. Hydroxylation of proline residues is critical for helix stability, …
characteristic triple-helix structure. Hydroxylation of proline residues is critical for helix stability, …
Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family
S Sinha, P Rappu, SC Lange… - Proceedings of the …, 1999 - National Acad Sciences
The yabJ gene in Bacillus subtilis is required for adenine-mediated repression of purine
biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular …
biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular …
[HTML][HTML] Feasibility of mechanical extrusion to coat nanoparticles with extracellular vesicle membranes
Biomimetic functionalization to confer stealth and targeting properties to nanoparticles is a
field of intense study. Extracellular vesicles (EV), sub-micron delivery vehicles for intercellular …
field of intense study. Extracellular vesicles (EV), sub-micron delivery vehicles for intercellular …
A Role for a Highly Conserved Protein of Unknown Function in Regulation of Bacillus subtilis purA by the Purine Repressor
P Rappu, BS Shin, H Zalkin… - Journal of …, 1999 - Am Soc Microbiol
Regulation of the purine biosynthetic gene purA was examined by using a transcriptional
fusion to a luciferase reporter gene. Transcription was repressed about 10-fold by the addition …
fusion to a luciferase reporter gene. Transcription was repressed about 10-fold by the addition …