Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown
fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent …

Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role
in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat …

Ferroptosis—an iron-dependent, non-apoptotic cell death process—is involved in various
degenerative diseases and represents a targetable susceptibility in certain cancers 1 . The …

Beige adipocytes are an inducible form of mitochondria-enriched thermogenic adipocytes
that emerge in response to external stimuli, such as chronic cold exposure. We have …

Stem cells are remarkably small. Whether small size is important for stem cell function is
unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to …

Adipose tissue fibrosis is a hallmark of malfunction that is linked to insulin resistance and type
2 diabetes; however, what regulates this process remains unclear. Here we show that the …

Brown fat and beige fat are known as thermogenic fat due to their contribution to non-shivering
thermogenesis in mammals following cold stimulation. Beige fat is unique due to its origin …

Brown and beige adipose tissues play a large role in non-shivering thermogenesis (NST) in
mammals, and subsequently have been studied for decades as potential therapeutic targets …

Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope
through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is …

Obesity and its related metabolic disorders are caused by an imbalance between homeostatic
energy consumption and expenditure. Brown and beige adipose tissues have been …