[HTML][HTML] Endogenous CRISPR-Cas system-based genome editing and antimicrobials: review and prospects

Y Li, N Peng - Frontiers in microbiology, 2019 - frontiersin.org
CRISPR-Cas systems adapt “memories” via spacers from viruses and plasmids to develop
adaptive immunity against mobile genetic elements. Mature CRISPR RNAs guide CRISPR-…

Archaeal extrachromosomal genetic elements

H Wang, N Peng, SA Shah, L Huang… - … and Molecular Biology …, 2015 - Am Soc Microbiol
Research on archaeal extrachromosomal genetic elements (ECEs) has progressed rapidly
in the past decade. To date, over 60 archaeal viruses and 60 plasmids have been isolated. …

[HTML][HTML] Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral …

…, H Liu, JH Naismith, M Sdano, N Peng… - Journal of Biological …, 2011 - ASBMB
In response to viral infection, many prokaryotes incorporate fragments of virus-derived DNA
into loci called clustered regularly interspaced short palindromic repeats (CRISPRs). The …

Harnessing Type I and Type III CRISPR-Cas systems for genome editing

…, S Pan, Y Zhang, M Ren, M Feng, N Peng… - Nucleic acids …, 2016 - academic.oup.com
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated)
systems are widespread in archaea and bacteria, and research on their molecular …

Genetic technologies for extremely thermophilic microorganisms of Sulfolobus, the only genetically tractable genus of crenarchaea

N Peng, W Han, Y Li, Y Liang, Q She - Science China Life Sciences, 2017 - Springer
Archaea represents the third domain of life, with the information-processing machineries more
closely resembling those of eukaryotes than the machineries of the bacterial counterparts …

Assignment of orthologous genes via genome rearrangement

X Chen, J Zheng, Z Fu, P Nan, Y Zhong… - IEEE/ACM …, 2005 - ieeexplore.ieee.org
The assignment of orthologous genes between a pair of genomes is a fundamental and
challenging problem in comparative genomics. Existing methods that assign orthologs based on …

[HTML][HTML] An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

N Peng, N Meng, SQ Wang, F Zhao, J Zhao, L Su… - Scientific reports, 2014 - nature.com
Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR)
and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very …

Prediction of postoperative lung function in patients with lung cancer: comparison of quantitative CT with perfusion scintigraphy

…, HK Hsu, HC Chang, NJ Peng… - American Journal of …, 2002 - Am Roentgen Ray Soc
OBJECTIVE. Prediction of postoperative lung function is important in preoperative evaluation
of patients with lung cancer. Perfusion scintigraphy is the current method to assess the …

A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti–hepatitis C target

…, G Huang, NF Peng, R Huang, WX Mao, S Peng… - Science …, 2016 - science.org
G-quadruplex (G4) is one of the most important secondary structures in nucleic acids. Until
recently, G4 RNAs have not been reported in any ribovirus, such as the hepatitis C virus. Our …

Geothermal area detection using Landsat ETM+ thermal infrared data and its mechanistic analysis—A case study in Tengchong, China

Q Qin, N Zhang, P Nan, L Chai - … Journal of Applied Earth Observation and …, 2011 - Elsevier
Thermal infrared (TIR) remote sensing is an important technique in the exploration of
geothermal resources. In this study, a geothermal survey is conducted in Tengchong area of …